Publications by authors named "Kay Hertel"
Article Synopsis
- The rise of personalized medicine has highlighted the importance of comprehensive genomic profiling (CGP), but challenges in assay standardization and understanding bioinformatics hinder uniform implementation.
- Two in-house CGP assays were compared in a research context, revealing both agreements and significant differences in detecting genetic variants and providing clinical recommendations.
- These discrepancies were attributed to varied bioinformatics methods for variant analysis, emphasizing the need for careful consideration in implementing high-quality CGP to ensure consistent and reliable genomic insights.
The existence of functionally relevant accessory olfactory organs in humans is still a matter of controversy. A vomeronasal organ (VNO) with sensory and non-sensory epithelia exists only in macrosmatic mammals. A similar structure is regularly observed in humans during fetal development.
View Article and Find Full Text PDFPathogenetic pathways of gastrointestinal stromal tumors (GIST) lacking mutations in KIT and PDGFRA (∼15%) are still poorly studied. Nearly nothing is known about PI3K alterations in GISTs and only a few GISTs with BRAF mutations have been reported. BRAF mutations (V600E) were found in 3/87 tumors (3.
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