An appreciation of the prescience of Don Gilbert (1930-2011): master of the theory and experimental unravelling of biochemical and cellular oscillatory dynamics.

We review Don Gilbert's pioneering seminal contributions that both detailed the mathematical principles and the experimental demonstration of several of the key dynamic characteristics of life. Long before it became evident to the wider biochemical community, Gilbert proposed that cellular growth and replication necessitate autodynamic occurrence of cycles of oscillations that initiate, coordinate and terminate the processes of growth, during which all components are duplicated and become spatially re-organised in the progeny. Initiation and suppression of replication exhibit switch-like characteristics, that is, bifurcations in the values of parameters that separate static and autodynamic behaviour.

Perceived effects of testosterone replacement therapy in perimenopausal and postmenopausal women: an internet pilot study.

Women experience somatic, mood, energy, and libido changes during menopause. Testosterone replacement therapy is being prescribed in conjunction with estrogen replacement therapy (ERT) for these symptoms. Little is known about women's perceptions of the benefits and risks of testosterone, so an Internet survey was conducted to elicit women's perceptions of the effects on mood, energy, sexuality, and somatic symptoms.