Synopsis of recent research by authors named "Kay Eckersley"
- Kay Eckersley's research primarily focuses on the development and characterization of novel enzyme inhibitors that have potential therapeutic applications in cancer treatment, particularly targeting DNA repair mechanisms and signaling pathways involved in tumor growth.
- A significant part of Eckersley's work involves the design of assays for measuring specific enzymatic activities, such as poly(ADP ribose) glycohydrolase (PARG) and USP7 deubiquitinating activity, which are crucial for understanding enzyme functions and their roles in cancer biology.
- Eckersley has contributed to the understanding of MTH1's role in cancer cell survival and investigated the efficacy of selective small molecule inhibitors against the RAS/RAF/MEK/ERK signaling pathway, providing insights into overcoming resistance in cancer therapies.
