Publications by authors named "Kawe Toutounian"
Article Synopsis
- The Thomsen-Friedenreich antigen (TFα) is a promising target for cancer vaccines, but synthetic versions have low effectiveness due to their weak immunogenicity.
- A newly isolated strain of gut bacterium, Bacteroides ovatus D-6, shows strong potential because it expresses the actual TFα antigen and induces a strong immune response in mice without the need for additional adjuvants.
- This strain’s unique combination of true TFα expression and its structural properties makes it an ideal candidate for developing a more effective anti-tumor vaccine.
Preliminary safety evaluation of a new Bacteroides xylanisolvens isolate.
Appl Environ Microbiol
January 2012
Besides conferring some health benefit to the host, a bacterial strain must present an unambiguous safety status to be considered a probiotic. We here present the preliminary safety evaluation of a new Bacteroides xylanisolvens strain (DSM 23964) isolated from human feces. First results suggest that it may be able to provide probiotic health benefits.
View Article and Find Full Text PDFSafety assessment of the commensal strain Bacteroides xylanisolvens DSM 23964.
Regul Toxicol Pharmacol
March 2012
We recently isolated and characterized the new strain Bacteroides xylanisolvens DSM 23964 and presented it as potential candidate for the first natural probiotic strain of the genus Bacteroides. In order to evaluate the safety of this strain for use in food, the following standard toxicity assays were conducted with this strain in both viable and pasteurized form: in vitro bacterial reverse mutation assay, in vitro chromosomal aberration assay, and 90day subchronic repeated oral toxicity studies in mice. No mutagenic, clastogenic, or toxic effects were detected even at extremely high doses.
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