Publications by authors named "Kawata R"

Background Tooth loss can impair masticatory function and may subsequently result in malnutrition. This study aimed to investigate the factors associated with controlling nutritional status (CONUT) scores, which assess malnutrition risk, in patients with removable dentures. Materials and methods In this cross-sectional study, data were obtained from a consecutive sampling of 192 patients (mean age 72.

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Objective: As Nepalese pregnant women vary widely in literacy levels and cultural backgrounds and are reluctant to make decisions about their health, general interventions are insufficient to improve maternal anemia. This study aimed to assess the effectiveness of "face-to-face health education using educational material created using pictures, photos, and nomograms" in reducing anemia and improving health literacy.

Methods: A total of 156 Nepalese pregnant women with hemoglobin (Hb) levels below 11.

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Article Synopsis
  • The study looked at a new treatment called BNCT for patients with laryngeal cancer who still had problems after getting radiation therapy and wanted to keep their voice.
  • 15 patients were treated with BNCT, and they all had surgeries to help with breathing before the treatment, just in case there were side effects.
  • Almost all patients (93.3%) showed positive results after 3 months, but some had temporary swelling in their throat, which usually got better within a week.
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Purpose: Since June 2020, boron neutron capture therapy (BNCT) has been a health care service covered by health insurance in Japan to treat locally advanced or recurrent unresectable head and neck cancers. Therefore, we aimed to assess the clinical outcomes of BNCT as a health insurance treatment and explore its role among the standard treatment modalities for head and neck cancers.

Materials And Methods: We retrospectively analyzed data from patients who were treated using BNCT at Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, between June 2020 and May 2022.

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Article Synopsis
  • The text indicates that there is a correction to a previously published article.
  • The article is identified by its DOI (Digital Object Identifier): 10.1371/journal.pone.0277770.
  • This correction aims to address errors or issues found in the original publication.
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We numerically analyze two-dimensional photonic crystal (PhC) nanocavities on glass with a thin glass film on top of the structure. We investigated a multistep heterostructure GaAs PhC nanocavity located on glass. We found that covering the structure even with a very thin glass film efficiently suppresses unwanted polarization mode conversion occurring due to the asymmetric refractive index environment around the PhC.

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  • Facial nerve paralysis from parotid carcinoma is often incorrectly diagnosed as Bell's palsy, and this study focused on comparing patients with and without facial nerve paralysis associated with the cancer.
  • Out of 209 patients, 42 (20%) had facial nerve paralysis, with 14 previously treated for paralysis who were misdiagnosed, while 28 were diagnosed with parotid carcinoma upon their first hospital visit.
  • Results indicated that patients with facial nerve paralysis suffered worse pain, had more aggressive tumors, and lower survival rates, suggesting that a thorough examination could help in making more accurate diagnoses and improving patient outcomes.
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Objective: The prognostic value of electroneurography (ENoG) for predicting the incidence of synkinesis is reportedly about 40 % using the formal standard method (ENoG-SM). However, the prognostic value of ENoG using the newly developed midline method (ENoG-MM) has not been determined. The aim of this study was to demonstrate the optimal prognostic value and advantages of ENoG-MM for predicting the incidence of synkinesis.

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Parotid salivary duct carcinoma (SDC) is a rare and aggressive parotid gland carcinoma (PGC). SDC has two origins: de novo and ex pleomorphic adenoma (SDC ex PA); however, because of its rarity, the clinical and molecular features of the two types of SDC are not sufficiently understood. Here, we studied the differences in their clinicopathological and molecular features using clinical specimens while comparing them to those of adenoid cystic carcinoma (AdCC), an intermediate-grade PGC.

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Objectives: Controversy exists on how to handle central lymph nodes in papillary thyroid carcinoma, particularly regarding indications for prophylactic central neck dissection (CND). Central node metastases are more difficult to diagnose preoperatively than lateral node metastases.

Methods: We enrolled 493 patients with papillary thyroid carcinoma treated at our department in the past 22 years.

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Background: The purpose of this study was to examine the factors influencing the prognosis of end-stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index.

Patients And Methods: This retrospective observational study included 79 patients with end-stage HNSCC. Patients were grouped by patient factors and prognostic indicators, and overall survival from the start of Best Supportive Care was compared for each group.

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Objective: High-grade parotid carcinoma generally has a poor prognosis, and the histological type is mucoepidermoid carcinoma (MEC), salivary duct carcinoma (SDC), carcinoma ex pleomorphic adenoma (CEPA), or adenoid cystic carcinoma (AdCC) in the majority of cases.

Methods: During the 23-year period from September 1999 to December 2022, 250 patients with parotid carcinoma underwent initial treatment and had the histopathological type of their carcinoma. Retrospective study evaluated 111 MEC, SDC, CEPA, or AdCC cases among 134 patients with high-grade parotid carcinoma.

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This is the first report of vestibular examinations before and after the successful treatment of vestibular migraine (VM), a common cause of recurrent vertigo, with calcitonin gene-related peptide (CGRP) receptor inhibitor. We evaluated a 42-year-old female with VM and concomitant probable Meniere's disease, whose headache and dizziness have improved promptly with the administration of erenumab, a CGRP receptor inhibitor. The sensorineural hearing loss in pure-tone audiometry, dysfunctions shown in vestibular examinations (cervical and ocular vestibular evoked myogenic potentials), and mild endolymphatic hydrops shown in gadolinium-enhanced inner ear magnetic resonance imaging, all in the right ear, revealed no change compared with those observed before treatment.

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Objective: Surgical airway management is one of the most effective techniques for safe airway management. Within the training programs relating to knowledge and skills required by otorhinolaryngologists, tracheostomy and postoperative management are important items that must be fully understood by airway surgeons. We performed a nationwide survey to identify problems within tracheostomy and postoperative management in Japan in order to establish practical and safe guidelines for surgical airway management.

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In parotid surgery, it is crucial to identify and preserve the facial nerve, which runs through the parotid gland. The purpose of this study was to histologically clarify two clinical questions: whether "superficial" and "deep" lobes exist anatomically and what are the structures surrounding facial nerve. Parotid gland tissues were obtained from dissection of donated cadavers.

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Article Synopsis
  • Adenoid cystic carcinoma (AdCC) of the salivary gland is a slow-growing cancer that can sometimes spread to distant sites, although not commonly through lymph nodes.
  • A study of 175 patients without lymph node metastasis identified key prognostic factors that influence disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS), particularly focusing on positive surgical margins and tumor stage.
  • The findings showed that patients with no positive prognostic factors (PS0) had significantly better 10-year survival rates compared to those with one or more positive factors (PS1, PS2), indicating the importance of these factors in predicting patient outcomes.
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Objective: Facial nerve paralysis is the most problematic complication of surgery for parotid tumors. This study aimed to examine the progress of recovery from postoperative transient facial nerve paralysis (POFNP).

Methods: Participants were 203 patients who developed POFNP after benign parotid surgery.

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Approximately 60% of adenoid cystic carcinoma (AdCC) cases are positive for MYB::NFIB or MYBL1::NFIB, whereas MYB/MYBL1 oncoprotein, a key driver of AdCC, is overexpressed in most cases. Juxtaposition of superenhancer regions in NFIB and other genes into the MYB/MYBL1 locus is an attractive oncogenic hypothesis for AdCC cases, either negative or positive for MYB/MYBL1::NFIB. However, evidence supporting this hypothesis is insufficient.

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Background: Prognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands.

Aims/objectives: To clarify the clinical characteristics of AdCC and examine factors associated with recurrence and prognosis by histopathological grade classification.

Materials And Methods: Twenty-five patients with AdCC of the parotid gland and 10 patients with AdCC of the submandibular gland were included.

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Article Synopsis
  • - Ricin toxin A chain (RTA) is a lethal protein that disrupts ribosomes by targeting a specific adenine in rRNA, making it a significant focus of study for potential inhibitors.
  • - Researchers have identified a potent inhibitor, -(pterin-7-carbonyl)glycyl-L-tyrosine, which demonstrates strong activity against RTA, but the exact mechanism of how it interacts with RTA was unclear before this study.
  • - This study utilized X-ray crystallography to reveal that the inhibitor interacts with RTA through a hydrogen bond and causes conformational changes in certain amino acids that enhance its inhibitory effectiveness.
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It has long been known that high-grade mucoepidermoid carcinoma (MEC) has a poor prognosis, but the detailed molecular and biological mechanisms underlying this are not fully understood. In the present study, the pattern of chymase-positive mast cells, as well as chymase gene expression, in high-grade MEC was compared to that of low-grade and intermediate-grade MEC by using 44 resected tumor samples of MEC of the parotid gland. Chymase expression, as well as chymase-positive mast cells, was found to be markedly increased in high-grade MEC.

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Objectives: To elucidate the differences between the cases of Meniere's disease (MD) with and without coexisting headaches, especially migraine. The clinical characteristics and vestibular functions are compared.

Subjects: Fifteen patients with definite unilateral MD without headaches (MD/H-; 10 males and 5 females; mean age of 55.

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Objectives: To investigate a method for predicting postoperative facial nerve paralysis (POFNP) during parotid surgery using intraoperative nerve monitoring (IONM).

Methods: We assessed prediction for POFNP by using IONM, comparing between stimulation in the facial nerve trunk and each branch by using facial nerve monitoring. The amplitude response ratio (ARR) was calculated for the trunk/periphery.

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Article Synopsis
  • Researchers aimed to create a new classification system for benign parotid tumors that links tumor location to the risk of postoperative facial nerve paralysis, a common complication after surgery.
  • They divided the parotid gland into six portions and combined them to establish eight specific tumor locations, using this categorization to analyze data from 948 patients.
  • Their findings revealed that pleomorphic adenomas were more prevalent in the upper gland and that tumors in deeper locations significantly increased the risk of facial nerve paralysis post-surgery.
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