Publications by authors named "Kawano F"

Background: While the incidence of early-onset cancers is rising, it is unclear whether this is the case for early-onset hepatocellular carcinoma (eHCC). Even the definition of eHCC remains unclear. This study was designed to identify an age cutoff for eHCC and to explore trends in its incidence, clinical presentation, surgical outcomes, and long-term survival compared to typical-onset HCC (tHCC).

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Introduction: The main text introduction expands on the initial introduction by providing a more detailed discussion of massive bleeding in elective surgeries and its challenges. It describes how traditional hemostatic procedures are essential but may not always be sufficient, especially in uncontrolled coagulopathy despite aggressive transfusion. It then introduces DCS as a well-established approach in trauma surgery, emphasizing its role in stabilizing patients with hemorrhagic shock, coagulopathy, hypothermia, and acidosis.

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Purpose: The dynamics of postoperative carcinoembryonic antigen (CEA) in pancreatic ductal adenocarcinoma (PDAC) patients have not been well assessed. This study investigated the correlation between postoperative CEA elevations and tumor recurrence.

Methods: Medical records were retrospectively analyzed for 84 patients who received curative resection for PDAC from January 2019 to December 2020.

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Background: Submucosal hemorrhage of the esophagus is relatively rare and the course of this disease remains unclear. We report a case of this disease.

Case Presentation: The patient was a 68-year-old man who visited a clinic complaining of sudden-onset epigastric and back pain.

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Background: Black esophagus, or acute esophageal necrosis (AEN), is a rare disease with a poor prognosis in which the esophageal mucosa is black in color. We report a case of esophageal perforation due to AEN that was successfully treated.

Case Presentation: An 88-year-old woman presented to her local hospital with the chief complaint of abdominal pain.

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Article Synopsis
  • * He was intubated and treated for acute respiratory distress syndrome (ARDS) with high-dose corticosteroids and ECMO, but did not improve and passed away 35 days later.
  • * The autopsy indicated diffuse alveolar damage and idiopathic diffuse alveolar hemorrhage linked to ARDS, highlighting the need to consider ARDS as a possible diagnosis after COVID-19 vaccination-related respiratory symptoms.
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  • Pulmonary colloid adenocarcinoma is a rare type of lung cancer, making its clinical features largely unknown; this report details a case of early-stage recurrence post-surgery.
  • A 68-year-old man was found to have colloid adenocarcinoma after a shadow was detected on a chest X-ray, leading to surgery where the cancer was initially removed and staged as early as possible (IA2).
  • Despite the belief that colloid adenocarcinoma has relatively slow progression, the case highlights that it can recur quickly, underscoring the need for following standard treatment guidelines for lung cancer.
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  • The study explored how aging affects the histone variant H3.3 in the tibialis anterior muscle of mice, finding that H3.3 levels significantly increase with age and correlate with the repressive marker H3K27me3.
  • Acute exercise enhanced gene expression in younger (8-week-old) mice but did not have the same effect in older (53-week-old) mice, who showed increased H3.3 and H3K27me3 levels at rest rather than in response to exercise.
  • Although H3.3 accumulation in older mice is linked to repressive chromatin formation, it also seems to improve motor function when H3.3 is artificially expressed in younger mice, indicating
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Introduction And Importance: We present a case of idiopathic azygos vein aneurysm (AVA) and describe its radiological features. Clinicians should be aware of the imaging findings to avoid the risk of bleeding caused by biopsy.

Case Presentation: An asymptomatic 46-year-old woman was found to have an abnormal shadow on a chest computed tomography (CT) scan during a medical checkup.

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Introduction And Importance: Bronchial foreign body aspiration is a life-threatening emergency. Largely, the published literature focuses on the removal of foreign bodies by bronchoscopy, while the surgical removal of endobronchial foreign bodies is rarely reported on. Thus, we presented a case of a bronchial foreign body that was successfully removed by a video-assisted thoracoscopic surgical (VATS) bronchotomy, after multiple failed bronchoscopic attempts.

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Purpose: To increase the number of medical students or residents who want to become surgeons, we must evaluate our program that recruits new young surgeons.

Methods: We planned surgical training programs for medical students and residents that we named the MANGOU (Miyazaki Advanced New General surgery Of University) training project in the Department of Surgery, Miyazaki University, Japan. From January 2016 through December 2022, we asked trainees who attended this training to complete questionnaires to evaluate their interest in surgery, confidence in surgical skills, and training.

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Purpose: Recently, bail-out cholecystectomy (BOC) during laparoscopic cholecystectomy to avoid severe complications, such as vasculobiliary injury, has become widely used and increased in prevalence. However, current predictive factors or scoring systems are insufficient. Therefore, in this study, we aimed to test the validity of existing scoring systems and determine a suitable cutoff value for predicting BOC.

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Background: Robotic pancreatoduodenectomy (RPD) is a newly introduced procedure, which is still evolving and lacks standardization. An objective assessment is essential to investigate the feasibility of RPD. The current study aimed to assess our initial ten cases of RPD based on IDEAL (Idea, Development, Exploration, Assessment, and Long-term study) guidelines.

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Article Synopsis
  • Enhanced IFNα production is linked to the development of systemic lupus erythematosus (SLE), particularly through the activation of the STING pathway in monocytes from SLE patients.
  • Research showed that SLE monocytes exhibited increased expression of GATA4, which elevates IFNα production and is associated with markers of cellular senescence like CDKN2A.
  • The study concluded that GATA4 plays a crucial role by binding to the enhancer regions of IFIT genes, thereby boosting the production of type I interferons, which are elevated in the context of SLE.
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Vibration acceleration (VA) using a whole-body vibration device is beneficial for skeletal muscles. However, its effect at the cellular level remains unclear. We aimed to investigate the effects of VA on muscles in vitro and in vivo using the C2C12 mouse myoblast cell line and cardiotoxin-induced injury in male rat soleus muscles.

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  • Conversion surgery for unresectable hepatocellular carcinoma is becoming more common due to new treatments, but long-term outcomes are still unclear.
  • A 75-year-old man with a large liver tumor and tumor thrombus successfully underwent conversion surgery after receiving lenvatinib, leading to significant tumor size reduction and improved vascularity.
  • After surgery, he has been disease-free for 32 months, with pathology indicating extensive necrosis in both the liver tumor and the tumor thrombus.
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Resection is the only potential curative treatment for perihilar cholangiocarcinoma (PHC); however, complete resection is often technically challenging due to the anatomical location. Various innovative approaches and procedures were invented to circumvent this limitation but the rates of postoperative morbidity (20%-78%) and mortality (2%-15%) are still high. In patients diagnosed with resectable PHC, deliberate and coordinated preoperative workup and optimization of the patient and future liver remnant are crucial.

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Introduction And Importance: We presented an extremely rare case of lung abscess following bronchoscopy associated with lung cancer that extended directly into the chest wall.

Case Presentation: A 49-year-old man with adenocarcinoma underwent bronchoscopy. Eight days after the biopsy, the patient presented with chills and anterior chest wall pain.

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Introduction And Importance: We present a relatively rare case of intrathoracic chronic expanding hematoma (CEH) after thoracic surgery for lung cancer. CEH is often difficult to distinguish from malignant tumors because of its large size and slow progressive enlargement. In this report, we describe the radiological features of CEH in detail.

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Introduction And Importance: Although pleomorphic adenoma is the most common type of parotid gland tumor, its occurrence in the trachea is rare. Here, we describe a successfully resected pleomorphic adenoma of the trachea in a woman with severe respiratory failure that had been preoperatively misdiagnosed as asthma.

Case Presentation: A 69-year-old woman presented to the emergency department with symptoms of worsening dyspnea and subsequent loss of consciousness.

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Background: Hyalinizing trabecular tumor is a rare follicular cell-derived thyroid neoplasm that is considered to be a borderline tumor with malignant potential rather than a benign tumor. The detection of RET/PTC rearrangements and nuclear cytologic features suggests a relationship between hyalinizing trabecular tumor and papillary thyroid carcinoma. Some recent observations of pathogenic genetic alterations in hyalinizing trabecular tumor have indicated that hyalinizing trabecular tumor is not related to papillary thyroid carcinoma, and should be considered an independent entity.

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Laparoscopic hepatectomy is safely performed with minimal invasiveness on patients with recurrent liver tumors after previous hepatectomy. However, it is still difficult to dissect and expose the operative field at the transected edge or plane after open right hepatectomy, even for limited resection by a laparoscopic approach, due to severe adhesion to the surrounding peritoneum or organs. We herein applied the retroperitoneal laparoscopic approach to limited resection of the dorsal surface at the transected edge of Couinaud's segment 6 after previous repeated hepatectomies in a patient with recurrent hepatocellular carcinoma (HCC) by avoiding severe intra-abdominal adhesion.

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