Comparative Evaluation of Penetration of Various Nano-sized Intra-canal Medicaments: An Confocal Laser Scanning Microscopic Study.

Background: To assess and contrast the depth of penetration of conventional calcium hydroxide, nanoparticle calcium hydroxide, silver nanoparticles, and combination of nanoparticle calcium hydroxide and silver nanoparticles into dentinal tubules using confocal laser scanning microscope.

Materials And Methods: Eighty human single-rooted teeth were decoronated and instrumented up to Protaper Universal F3. Teeth were separated into four groups at random ( = 20) following chemomechanical preparation.

A comparative study on surgical outcomes of trabeculectomy with and without anti-metabolites in juvenile open-angle glaucoma.

Purpose: To compare the surgical outcomes of trabeculectomy with and without anti-metabolites in patients with juvenile open-angle glaucoma (JOAG).

Methods: This retrospective comparative case series included 98 eyes of 66 patients with JOAG who underwent either trabeculectomy without anti-metabolites (group A, n = 53 eyes) or with anti-metabolites (group B, n = 45 eyes) with a minimum of 2 years follow-up. The main outcome measures were intra-ocular pressure (IOP), number of glaucoma medications, visual acuity, additional surgical interventions, surgical complications, and risk factors for failure.

Molecular dynamics simulation study on EngA: the presence of Mg at the active-sites promotes the functionally important conformation.

EngA, a GTPase contains two GTP binding domains [GD1, GD2], and the C-terminal KH domain shown to be involved in the later stages of ribosome maturation. Association of EngA to the ribosomal subunit in the intermediate stage of maturation is essential for complete ribosome maturation. However, this association was shown to be dependent on the nucleotide bound combinations.

A cationic amino acid polymer nanocarrier synthesized in supercritical CO for co-delivery of drug and gene to cervical cancer cells.

The present study was undertaken to investigate the ability of a drug curcumin-loaded polymer to inhibit the growth of cervical cancer cells by enhancing the anti-cancer efficiency of curcumin. We synthesized poly(methacryloyl beta-alanine) (PMBA) as a nanocarrier by radical polymerization in supercritical CO. The results showed that the curcumin encapsulated and folic acid (FA)-treated PMBA (Poly@Cur-FA) for 24 h activated the reactive oxygen species-mediated programmed cell death machinery in HeLa cells.

To Compare the Accuracy of 0.022 Inch Slot of Stainless Steel and Ceramic Orthodontic Brackets Marketed by Different Manufacturers.

Aim Of The Study: The aim of the present study was to analyze the accuracy of 0.022 inch slot of stainless steel and ceramic orthodontic brackets marketed by different manufacturers.

Materials And Methods: An study was done on upper left central incisor bracket of MBT 0.

Graphitic carbon nitride/NH-MIL-101(Fe) composite for environmental remediation: Visible-light-assisted photocatalytic degradation of acetaminophen and reduction of hexavalent chromium.

Herein, an efficient photocatalyst composed of graphitic carbon nitrate and iron-based metal-organic framework (g-CN/NH-MIL-101(Fe)) composite was fabricated by a solvothermal method for the degradation of acetaminophen (AAP) and reduction of Cr(VI) under sunlight illumination. The composite was confirmed by X-ray diffraction. UV-visible spectra showed that the bare g-CN, pure Fe-MOF, and composite harvest solar light effectively.

Metal-organic frameworks with different oxidation states of metal nodes and aminoterephthalic acid ligand for degradation of Rhodamine B under solar light.

Metal-organic frameworks (MOFs) have been investigated recently as effective visible light photocatalysts. In this report, we synthesized nickel, iron, and titanium-based MOFs with different oxidation states of metal ions and aminoterephthalic acid ligand for photocatalytic degradation of Rhodamine B (RhB) dye under solar light irradiation. The photoluminescence analysis revealed that the Fe-MOF could suppress the recombination of photoinduced charges and effectively degrade the dye.

Protein kinases orchestrate cell cycle regulators in differentiating BeWo choriocarcinoma cells.

Choriocarcinoma, a trophoblastic neoplasia, occurs in women as an incidence of abnormal pregnancy. BeWo choriocarcinoma cells derived from the abnormal placentation are a suitable model system to study the factors associated with differentiation, invasion and other cellular events as an alternative to clinical samples. Many protein kinases orchestrate the complex events of cell cycle and in case of malignancy such regulators are found to be mutated.

Simultaneous Clustering and Feature Weighting Using Multiobjective Optimization for Identifying Functionally Similar miRNAs.

MicroRNAs (miRNAs) are a type of RNAs, which are responsible for monitoring the gene expression values. Recent research asserts that miRNAs form some clustering on chromosomes. The miRNAs belonging to a particular cluster are highly similar in terms of their activity and they are termed as "coregulated" miRNAs.

Efficacy of different methods for detecting the onset of ovarian cyclicity in post-partum Murrah buffaloes.

This study was designed to investigate the sensitivity and specificity of three methods for detecting the onset of cyclicity in post-partum Murrah buffaloes. The methods investigated were visual signs, transrectal ultrasonography, and serum progesterone (P) assay. For this study, 102 post-partum Murrah buffalo cows were grouped for monitoring their ovarian activity.

Dexamethasone inhibits inflammatory response via down regulation of AP-1 transcription factor in human lung epithelial cells.

The production of inflammatory mediators by epithelial cells in inflammatory lung diseases may represent an important target for the anti-inflammatory effects of glucocorticoids. Activator protein-1 is a major activator of inflammatory genes and has been proposed as a target for inhibition by glucocorticoids. We have used human pulmonary type-II A549 cells to examine the effect of dexamethasone on the phorbol ester (PMA)/Lipopolysaccharide (LPS) induced pro-inflammatory cytokines and AP-1 factors.

Correlations Between Anthropometry and Lipid Profile in Women With PCOS.

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women and is associated with both reproductive and metabolic abnormalities. Recent studies have demonstrated an early onset of abnormal cardiovascular risk profile in women with PCOS. Abnormal lipid profile patterns are common in women with PCOS, and these abnormalities are not uniform in all populations.

The Effect of Moderate Physical Activity on Ovarian Reserve Markers in Reproductive Age Women Below and Above 30 Years.

Background: There is significant evidence among the general population regarding the impact of physical activity in improving the quality of life; however, evidence regarding the effect of physical activity in improving fertility and the quality of life in infertile women is inadequate. Existing medical literature shows that moderately regular physical activity positively influences ovarian reserve and assisted reproductive technology (ART) outcomes in overweight and obese women. It is not known whether moderate physical activity influences ovarian reserve in normal weight reproductive age women, and whether age has any influence on the physical activity related changes in ovarian reserve.

Ovulatory and fertility response using modified Heatsynch and Ovsynch protocols in the anovular Murrah buffalo (Bubalus bubalis).

We studied the effect of modified Heatsynch and Ovsynch protocols on the ovulatory response (OR), estrus induction rate (EIR) and conception rate (CR) in the anovular postpartum Murrah buffalo (n = 35). In the modified Heatsynch protocol (Group I; n = 12), buffaloes were given two GnRH at 2 h interval on treatment day 0, PGF (PGF2α) on day 7 and estradiol (E) 1 mg on day 8. Two FTAI were done at 20 h intervals after E administration.

Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status.

Androgen receptor (AR) signaling axis plays a vital role in the development of prostate and critical in the progression of prostate cancer. Androgen withdrawal initially regresses tumors but eventually develops into aggressive castration-resistant prostate cancer (CRPC). Activator Protein-1 (AP-1) transcription factors are most likely to be associated with malignant transformation in prostate cancer.

Optimal feed profile for the Rhamnolipid kinetic models by using Tabu search: metabolic view point.

Rhamnolipids are bio surfactants which are extra-cellular glycolipids composed of L-rhamnose and 3-hydroxyalkanoics. Rhamnolipids are produced through fermentation process by using Pseudomonas sp. as the species.

Cadmium induces oxidative stress and apoptosis in lung epithelial cells.

Cadmium (Cd) is one of the well-known highly toxic environmental and industrial pollutants. Cd first accumulates in the nucleus and later interacts with zinc finger proteins of antiapoptotic genes and inhibit the binding of transcriptional factors and transcription. However, the role of Cd in oxidative stress and apoptosis is less understood.

Interplay of nuclear receptors (ER, PR, and GR) and their steroid hormones in MCF-7 cells.

Steroid hormones and their nuclear receptors play a major role in the development and progression of breast cancer. MCF-7 cells are triple-positive breast cancer cells expressing estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). However, interaction and their role in expression pattern of activator protein (AP-1) transcription factors (TFs) are not completely understood.

Pityriasis Rosea Localized to the Skin Patches of Leprosy. A Wolf's Isotopic Response?

Pityriasis rosea is one of the commonly encountered papulo squamous disease in dermatology outpatient department. Its clinical presentations are varied, and it also has many atypical forms. We report a case of a male patient with classical Pityriasis rosea lesions limited to the patches of Hansen's disease.

Advances in reproductive biotechnologies.

In recent times, reproductive biotechnologies have emerged and started to replace the conventional techniques. It is noteworthy that for sustained livestock productivity, it is imperative to start using these techniques for facing the increasing challenges for productivity, reproduction and health with impending environment conditions. These recent biotechniques, both in male and female, have revolutionized and opened avenues for studying and manipulating the reproductive process both in vitro and in vivo in various livestock species for improving tis efficiency.

LC-MS/MS profiling and neuroprotective effects of Mentat® against transient global ischemia and reperfusion-induced brain injury in rats.

Objective: The aim of this study was to evaluate the possible beneficial effects of Mentat against transient global ischemia and reperfusion-induced brain injury in rats.

Methods: The neuroprotective effects of Mentat were evaluated against transient global ischemia and reperfusion (I/R)-induced brain injury in rats. Various neurobehavioral and biochemical parameters were assessed, followed by morphologic and histopathologic evaluation of brain tissue to conclude the protective effect of Mentat.

An improved experimental model of hemorrhoids in rats: evaluation of antihemorrhoidal activity of an herbal formulation.

Objective. To improve the existing experimental model of croton oil-induced hemorrhoids in rats by using Evans Blue (EB) dye extravasation technique. Further, an herbal formulation (Pilex) was evaluated for its antihemorrhoidal activity in this model.

Ameliorative effect of Koflet formulations against pyridine-induced pharyngitis in rats.

In present study two formulations of Koflet (syrup and lozenges) were evaluated against pyridine-induced pharyngitis in rats. Topical application of 10% pyridine showed extravasation of Evans blue stain as a characteristic feature of on-going inflammation. In addition, the levels of TNF-α ( < 0.

Evaluation of Bacopa monniera for its synergistic activity with rivastigmine in reversing aluminum-induced memory loss and learning deficit in rats.

The objective of this study was to evaluate the synergistic activity of Bacopa monniera with Rivastigmine against aluminum-chloride (AlCl3)-induced cognitive impairment in rats. Adult male Wistar rats were divided into ten groups (n = 10) and subjected to their assigned treatments for 42 days. On the 20(th) day of the respective drug treatments, all the animals were trained in the Morris water maze (retention latency) and the elevated plus maze (transfer latency).

Fabrication and characterization of chitosan/gelatin/nSiO2 composite scaffold for bone tissue engineering.

A 3D nanocomposite scaffold of chitosan, gelatin and nano-silica was fabricated by lyophilization to test the hypothesis that incorporation of nano-SiO2 could produce a better candidate for bone tissue engineering compared to pure chitosan and chitosan/gelatin scaffolds. The prepared scaffold was characterized using SEM and FTIR. Porosity, density, swelling, degradation, mechanical integrity, biomineralization and protein adsorption studies, favored it in comparison to the conventional chitosan and chitosan/gelatin scaffolds.