Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices.

Background: Inflammatory bowel disease (IBD) is increasingly diagnosed in South Asia. This survey by the Tamil Nadu Chapter of the Indian Society of Gastroenterology (TNISG) documents the demography, clinical profile, and therapeutic practices related to IBD in Tamil Nadu.

Methods: TNISG members from 32 institutions completed an online cross-sectional questionnaire on IBD patients from March 2020 to January 2021.

Optimization of process using carboxymethyl chitosan for the removal of mixed heavy metals from aqueous streams.

This paper highlights the efficacy of carboxymethyl chitosan (CMCh), a bio-degradable water-soluble derivative of chitosan for the separation of a mixture of heavy metal ions such as copper, nickel, zinc and lead from aqueous streams, as they constitute, the major industrial pollutants present in wastewater. The experimental studies are conducted using commercially available ultrafiltration module using synthetic solutions of the contaminants. The design of experiments was performed by Response Surface Methodology (RSM) with split-plot D-optimal design.

Removal and recovery of heavy metals through size enhanced ultrafiltration using chitosan derivatives and optimization with response surface modeling.

N‑N‑N‑triethylammonium chitosan (TEAC) and carboxymethyl chitosan (CMCh), the two water-soluble chitosan derivatives were utilized for the removal and recovery of heavy metals by size enhanced ultrafiltration (SEUF). The strong positive quaternary ammonium [-N(CH)] cation in TEAC interacts with Cr(VI), which exists as a strong chromate anion thereby enabling the efficient removal of chromate through ultrafiltration. CMCh consists of COOH and NH moieties, which facilitate interactions with heavy metals such as Cu(II) and Ni(II).

Prevalence of bla (CTX M) extended spectrum beta lactamase gene in enterobacteriaceae from critical care patients.

Context: Critical care units provide a favourable environment for the antimicrobial resistant organisms to disseminate. There is recent increase in number of extended spectrum beta lactamase (ESBL) producers because of the emergence of CTX M Beta lactamases produced by Enterobacteriaceae. They colonize the intestinal flora and spread with greater intensity in the community and hospital.

Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents.

A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. The starting material 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one was synthesized from 2-methyl aniline by a novel innovative route. The title compounds were tested for their in vivo H(1)-antihistaminic activity on guinea pigs; all the tested compounds protected the animals from histamine-induced bronchospasm significantly.