Efficacy and safety of elobixibat in patients with chronic constipation-A randomized, multicenter, double-blind, placebo-controlled, parallel-group study from India.

Background: Elobixibat is a locally acting ileal bile acid transporter (IBAT) inhibitor that relieves functional constipation in patients by accelerating colonic transit. In this study, we aimed at determining the efficacy and safety of elobixibat for short-term treatment (two weeks) of chronic constipation in Indian patients.

Methods: The present study was a randomized, double-blind, parallel-group, placebo-controlled, phase III study to evaluate efficacy and safety of elobixibat.

Fabrication of chitosan/fibrin-armored multifunctional silver nanocomposites to improve antibacterial and wound healing activities.

A wound healing substitute promotes rapid tissue regeneration and protects wound sites from microbial contamination. The silver-based antiseptic frequently moist skin stains, burns and irritation, penetrates deep wounds and protects against pathogenic infections. Thus, we formulated a novel fibrin/chitosan encapsulated silver nanoparticle (CH:F:SPG-CH:SNP) composites bandage accelerating the polymicrobial wound healing.

Gendered Pattern and Predictors of Tobacco use in India: Evidence from the Second Round of Global adult Tobacco Survey.

Background: India has completed the second round of the Global Adult Tobacco Survey (GATS) to monitor adult tobacco use and progress in tobacco control efforts. This study assesses the gendered pattern of tobacco use and its predictors in the second rounds of GATS.

Material And Methods: Publicly available GATS-2 (2016-2017) data was analyzed which contains self-reported tobacco use information of ≥15 years Indians ( = 74,037).

A Secure Long-Range Transceiver for Monitoring and Storing IoT Data in the Cloud: Design and Performance Study.

Due to the high demand for Internet of Things (IoT) and real-time data monitoring and control applications in recent years, the long-range (LoRa) communication protocols leverage technology to provide inter-cluster communications in an effective manner. A secure LoRa system is required to monitor and store IoT data in the cloud. This paper aims to report on the design, analysis, and performance evaluation of a low-cost LoRa transceiver interface unit (433 MHz band) for the real-time monitoring and storing of IoT sensor data in the cloud.

Targeting COVID-19 pandemic: in silico evaluation of 2-hydroxy-1, 2-diphenylethanone N(4)-methyl-N(4)-phenylthiosemicarbazone as a potential inhibitor of SARS-CoV-2.

Unlabelled: The global spread of the COVID-19 pandemic caused by the etiological agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), triggered researchers to identify and develop novel antiviral therapeutics. Herein, we report a new molecule 2-hydroxy-1,2-diphenylethanone N(4)-methyl-N(4)-phenyl thiosemicarbazone (BMPTSC), as a potential inhibitor of SARS-CoV-2. BMPTSC was synthesized, characterized by IR and NMR studies, and the structural parameters were analyzed computationally by B3LYP/cc-pVDZ method.

Increasing Risk Factors for Non-Alcoholic Fatty Liver Disease; an Insight into Chronic Periodontitis and Insulin Resistance.

Non-alcoholic fatty liver disease (NAFLD) is marked by the excessive intrusion of triglycerides into hepatocytes without any role of alcohol consumption. Various risk factors have been attributed to this disease pathogenesis, including metabolic disorders, immune response, and even an intricate relationship between the two. The role of insulin resistance (IR) in NAFLD has long been known; however, the molecular basis of disease progression under this metabolic backdrop is still being investigated.

Out-of-pocket health expenditure on diarrheal illness among under-five children in a teaching hospital ins Odisha, India.

Background: Diarrhea is the most common illness in children under 5 years of age, accounting for a financial burden for families in developing countries.

Objective: The aim of this study is to determine the out-of-pocket health expenditure for the management of diarrhoeal illness among the under-five children in in-patient and out-patient cases.

Methods: A cross-sectional study was conducted during January-April 2018 among 60 under-five children with diarrheal illness reporting to pediatric outpatient department (OPD) and 60 under-five children admitted to pediatric ward of a tertiary care teaching hospital.

Corrigendum: Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India.

[This corrects the article DOI: 10.3389/fmicb.2017.

Investigations on the Functional connectivity disruptive patterns of progressive neurodegenerative disorders.

Alzheimer's Disease (AD) and Parkinson's Disease (PD) are neurodegenerative diseases of the brain that affects the memory and motor regions respectively. Neurological disorders are the result of alterations at molecular level due to complex mechanisms between genetic and environmental factors. Classical approaches are focused on determining how disruptions in functional connectivity occur in the memory regions of AD and motor regions of PD.

Prevalence and risk indicators of oral mucosal lesions in adult population visiting primary health centers and community health centers in Kodagu district.

Background And Objective: Utilization of primary health center (PHC) and community health center (CHC) could be one of the few practical approaches in early detection of oral cancers and potentially malignant disorder (PMD). This study was designed to estimate the prevalence and distribution of oral mucosal lesion (OML) and its associated risk factors among the adult population of Kodagu district.

Methodology: 1048 patients, 18 years of age and above, attending the outpatient department of PHC and CHC in Kodagu district comprised the study population.

Independent urban effect on hypertension of older Indians: identification of a knowledge gap from a Study on Global AGEing and Health.

Among older Indians, more cardiovascular diseases and risk factors are observed in the city dwellers than in the rural population. Clustering of socioeconomic privileges and consequent obesity in the Indian cities are known to underlie this phenomenon. But, it is unclear whether an independent urban effect exists on age-related ailments, unexplained by concentration of privileges and excess weight in the Indian cities.

Primary mucinous carcinoma of skin with a trichoadenomatous component: A rare case report.

Primary mucinous carcinoma of the skin is a rare subtype of eccrine sweat gland tumors. Differentiating it from metastatic adenocarcinomas is important in the management of this condition. We report the case of a 55-year-old female presenting with a painless nodule, which was subsequently diagnosed as primary mucinous carcinoma of skin with a trichoadenomatous component.

Correction to: Extraction and bioactive profile of the compounds produced by sp. VLD-10.

[This corrects the article DOI: 10.1007/s13205-016-0576-6.].

Biological Significance of Marine Actinobacteria of East Coast of Andhra Pradesh, India.

An attempt was made to identify actinobacterial strains present in the marine soil of East Coast regions ., Chirala, Bapatla, and Peddaganjam, Andhra Pradesh; Kanyakumari, Tamil Nadu and Goa, Goa along with the study of their antimicrobial potential. Eight out of 73 actinobacterial strains isolated from these regions showed strong antimicrobial activity against Gram positive bacteria, Gram negative bacteria, and .

Epidemiology and clinico-investigative study of organisms causing vaginal discharge.

Background: Abnormal vaginal discharge is a common clinical problem in reproductive age group. It is the second most common problem after abnormal uterine bleeding. It is a neglected health problem, most commonly caused due to vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis (BV).

Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers.

Objective: The aim of the study was to compare the treatment effects of 5% amlexanox and low-level laser therapy (LLLT) in a cohort of patients who experienced minor aphthous stomatitis.

Study Design: A clinical trial was performed between 2012 and 2014 on 50 participants having minor aphthous ulcers. Group A participants were treated with amlexanox oral paste (lexanox 5% oral paste), and group B participants were treated with LLLT.

Extraction and bioactive profile of the compounds produced by Rhodococcus sp. VLD-10.

A potent actinobacterial strain isolated from the marine samples of Bheemunipatnam beach, Visakhapatnam, India, was identified as Rhodococcus sp. VLD-10 using the conventional and genomic (16S rRNA) approaches. Bioactive compounds responsible for the antimicrobial activity of the strain were elucidated by cultivating the strain VLD-10 in a modified yeast extract-malt extract-lactose broth followed by subsequent chromatographic and spectroscopic analyses.

Comparative evaluation of ELISA and dot-blot for the diagnosis of tuberculous meningitis.

Tuberculous meningitis is a central nervous system tuberculosis caused by M. tuberculosis. It causes high mortality if delayed in diagnosis and treatment.

Magnetite nanoparticles-chitosan composite containing carbon paste electrode for glucose biosensor application.

This work was aimed to develop reusable magnetite chitosan composite containing carbon paste electrode for biosensor application. Glucose oxidase (GOx) enzyme was used to prepare GOx-magnetite-chitosan nanocomposite containing carbon paste electrode for sensitive detection of glucose. The immobilized enzyme retained its bioactivity, exhibited a surface confined reversible electron transfer reaction, and had good stability.

Possible significance of anti-heat shock protein (HSP-65) antibodies in autoimmune myasthenia gravis.

Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host against various insults.

A study on L-asparaginase of Nocardia levis MK-VL_113.

An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized. Maximal yields of L-asparaginase were recorded from 3-day-old culture grown in modified asparagine-glycerol salts broth with initial pH 7.

Prevalence of bla (CTX M) extended spectrum beta lactamase gene in enterobacteriaceae from critical care patients.

Context: Critical care units provide a favourable environment for the antimicrobial resistant organisms to disseminate. There is recent increase in number of extended spectrum beta lactamase (ESBL) producers because of the emergence of CTX M Beta lactamases produced by Enterobacteriaceae. They colonize the intestinal flora and spread with greater intensity in the community and hospital.

A randomized controlled trial to study the effect of IV hydration on the duration of labor in nulliparous women.

Purpose: To compare the effects of two different regimens of intravenous hydration and oral hydration on the duration of active labor.

Methods: Two hundred and ninety-three low risk term primigravida in active labor were randomized into three groups. The first group had 99 patients who received oral fluids only, the second group of 98 patients received intravenous Ringer lactate at the rate of 125 ml/h (IV 125 ml) and the third group had 96 patients who received intravenous Ringer lactate at a rate of 250 ml/h (IV 250 ml).