Bisindole Alkaloids from a New Zealand Deep-Sea Marine Sponge .

Chemical investigation of the secondary metabolites of a rare New Zealand deep-sea sponge, , resulted in the isolation of twenty-one indole alkaloids, including two new bisindoles-()-coscinamide D (), ()-coscinamide D ()-and four compounds isolated for the first time as natural products-lamellomorphamides A (), B (), C () and D (). In addition, fifteen previously reported natural products were isolated, seven of which are seco analogs of hamacanthin alkaloids. The one sponge produces enantiomerically pure but opposite configurations of compounds that only differ in the number of bromines, suggesting enantiodivergent biosynthesis.

Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans.

Two new steroids, crellasterones A () and B (), together with the previously reported compound chalinasterol () and several nucleosides (-), were isolated from the sponge , collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.

Enantiodivergence in the Biosynthesis of Bromotyrosine Alkaloids from Sponges?

The isolation of bromotyrosine alkaloids, some of which are enantiomers of previously isolated compounds, has highlighted a possible enantiodivergence in their biosynthesis. Two new (1, 2) and six known bromotyrosine alkaloids (4-9), and the enantiomer (10) of a known compound, have been isolated from a Western Australian marine sponge, Pseudoceratina cf. verrucosa.

Investigations of the marine flora and fauna of the Fiji Islands.

Over the past 30 years, approximately 140 papers have been published on marine natural products chemistry and related research from the Fiji Islands. These came about from studies starting in the early 1980s by the research groups of Crews at the University of California Santa Cruz, Ireland at the University of Utah, Gerwick from the Scripps Institution of Oceanography, the University of California at San Diego and the more recent groups of Hay at the Georgia Institute of Technology (GIT) and Jaspars from the University of Aberdeen. This review covers both known and novel marine-derived natural products and their biological activities.