Catechin inhibits glycosidases, ameliorates glucose uptake and Glut-4 expression in 3T3-L1 adipocytes.

The research aimed to determine the inhibitory effects of different fractions of on α-glucosidase, α-amylase, glucose uptake, and Glut-4 expression in 3T3-L1 adipocytes and identification of the active principle. The crude aqueous extract was sequentially sub-fractionated using preparative HPLC and subjected to assays. Fraction 1 (F1) exhibited effective inhibition of both α-glucosidase and α-amylase with an IC value of 90.

Nesfatin-1-like peptide is a novel metabolic factor that suppresses feeding, and regulates whole-body energy homeostasis in male Wistar rats.

Nucleobindin-1 has high sequence similarity to nucleobindin-2, which encodes the anorectic and metabolic peptide, nesfatin-1. We previously reported a nesfatin-1-like peptide (NLP), anorectic in fish and insulinotropic in mice islet beta-like cells. The main objective of this research was to determine whether NLP is a metabolic regulator in male Wistar rats.

Metabolic and Cardiovascular Actions of Nesfatin-1: Implications in Health and Disease.

Background: Metabolic homeostasis is achieved by proper functioning of a complex endocrine milieu, comprising of signals arising from the brain and peripheral tissues. Our knowledge of the factors regulating such balance is rapidly evolving, as new signaling molecules are being characterized. Of central interest is nesfatin-1, owing to its multifunctional tissue specific actions regulating food intake, body weight, blood glucose and cardiac functions.

Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit.

Context: Cucumis prophetarum Linn. (Cucurbitaceae) fruit is used for inflammatory-related problems and is proved to be possessing anticancer and hepatoprotective effects.

Objective: The present investigation was to study the effect of different fractions of C.