Evaluating the Role of the Endocannabinoid System in Axon Guidance: A Literature Review.

The endocannabinoid system (ECS) mediates the actions of cannabis and has been implicated in playing critical roles in key developmental events, including axon guidance. Although several recent studies have demonstrated ECS involvement in neurodevelopment, an emphasis on its putative role in axon guidance has not been reviewed comprehensively. The purpose of this literature review is to evaluate the interrelationships between the ECS and axon guidance.