Publications by authors named "Kaveri S Parker"
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood syndrome affecting up to 6.5% of adult women in the U.S.
View Article and Find Full Text PDFIncreasing antibiotic resistance among uropathogenic (UPEC) is driving interest in therapeutic targeting of nonconserved virulence factor (VF) genes. The ability to formulate efficacious combinations of antivirulence agents requires an improved understanding of how UPEC deploy these genes. To identify clinically relevant VF combinations, we applied contemporary network analysis and biclustering algorithms to VF profiles from a large, previously characterized inpatient clinical cohort.
View Article and Find Full Text PDFArticle Synopsis
- Uropathogenic Escherichia coli produce siderophores, like yersiniabactin, which help them acquire metals during urinary tract infections, notably binding to copper ions as well as iron.
- A mass spectrometric study revealed that yersiniabactin forms stable complexes with various metals, including nickel, cobalt, and chromium, in addition to iron and copper.
- The outer membrane importer FyuA facilitates the uptake of these metal complexes in a TonB-dependent manner, with copper(II)-yersiniabactin being structurally unique and not inhibiting the import of iron(III) yersiniabactin.