Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in .

Fun30, an ATP-dependent chromatin remodeler from , is known to mediate both regulation of gene expression as well as DNA damage response/repair. The Fun30 from has not yet been elucidated. We show that Fun30 is functionally homologous to both Fun30 and human SMARCAD1.

Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling.

Active DNA-dependent ATPase A Domain inhibitor (ADAADi) is the only known inhibitor of ATP-dependent chromatin remodeling proteins that targets the ATPase domain of these proteins. The molecule is synthesized by aminoglycoside phosphotransferase enzyme in the presence of aminoglycosides. ADAADi interacts with ATP-dependent chromatin remodeling proteins through motif Ia present in the conserved helicase domain, and thus, can potentially inhibit all members of this family of proteins.