Publications by authors named "Kaustubh Sanjay Nadkarni"
Histone ubiquitination: Role in genome integrity and chromatin organization.
Biochim Biophys Acta Gene Regul Mech
September 2024
Article Synopsis
- Maintaining genome integrity is a complex task for cells, heavily influenced by post-translational modifications (PTMs), particularly ubiquitination, which affects both nonhistone and histone proteins and their role in chromatin structure.
- Ubiquitination of core histones and linker histones is crucial for various cellular functions, but understanding how it interacts with other PTMs and affects chromatin dynamics remains a challenge.
- This review explores the types of histone ubiquitination and their significance in genomic integrity, and highlights the need for further research on the interplay between histone ubiquitination, other PTMs, and deubiquitination enzymes (DUBs) in regulating cellular processes.