Publications by authors named "Kaushik Pal"

Tuning of photophysical characteristics of small molecule fluorophores by simple synthetic method is desired but possesses its own challenges. We are reporting here an easy-to-achieve synthetic strategy to tune N-H maleimide-based fluorescent small molecules 2a-c to achieve large Stokes shifted solvatochromism and aggregation induced emission (AIE) via. π-surface extension.

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Novel studies on typical synthesized magnetite nanoparticles were encapsulated into a poly (butylene succinate)/poly (ethylene glycol) copolymer (PBS-PEG). PBS was chosen because of its biocompatibility characteristics necessary for biomedical applications. PEG, as part of the macromolecular structure, increases the hybrid system's solubility in an aqueous environment, increasing the circulation time of the material in the bloodstream.

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Many micro-particles including pathogens strongly adhere to hosts. It remains elusive how macrophages detach these surface-bound particles during phagocytosis. We show that, rather than binding directly to these particles, macrophages form unique β integrin-mediated adhesion structures at the cell-substrate interfaces, specifically encircling the surface-bound particles.

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Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal photothermal conversion, and poor biostability and biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped CuS (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity for pH-responsive OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions.

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Investigations of the biological system have revealed many principles that govern regular life processes. Recently, the analysis of tiny mechanical forces associated with many biological processes revealed their significance in understanding biological functions. Consequently, this piqued the interest of researchers, and a series of technologies have been developed to understand biomechanical cues at the molecular level.

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  • The study explores a new cancer treatment approach that combines near-infrared laser phototherapies with chemotherapy, aiming to improve effectiveness while minimizing invasiveness and side effects.
  • CuO nanoparticles were modified with a photosensitizer, chlorin e6, and coated with polydopamine to create a multifunctional drug delivery system that enhances targeted therapy.
  • In vitro and in vivo experiments demonstrated that this nanoplatform, when used with laser irradiation, effectively increases cancer cell death and shows promise as a combined treatment strategy for better cancer management.
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  • The study examines the use of bioabsorbable materials, specifically polylactic acid (PLA) and hydroxyapatite (HAP), for maxillofacial reconstruction to avoid issues with traditional metallic implants.
  • It involves creating and testing several PLA-based nanocomposites with properties that improve strength and bioactivity, using techniques like ball milling and sol-gel methods for nanoparticle preparation.
  • Results show that the developed composites, PEAT and PHAT, exhibit favorable mechanical properties and cell viability, suggesting they are promising candidates for future use in maxillofacial implants.
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This study explores the impacts of neem oil biodiesel (BD), which was produced and characterized using GC-MS, FTIR, and UV-Vis spectroscopic techniques to elucidate pure and corrosion-product neem oil BD at room temperature (25 °C) and different immersion durations of 0, 28, 42, and 56 days. The OM and SEM were also employed to study the surface, structural integrity, and interphase interaction between the BD and the carbon steel (C1020) before and after immersion for different durations. The dominant fatty acid (FA) group in both pure and corrosion-product neem oil BD was C, with a total composition of 72.

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From 1990 to 2024, this study presents a groundbreaking bibliometric and sentiment analysis of nanocomposite literature, distinguishing itself from existing reviews through its unique computational methodology. Developed by our research group, this novel approach systematically investigates the evolution of nanocomposites, focusing on microstructural characterization, electrical properties, and mechanical behaviors. By deploying advanced Boolean search strategies within the Scopus database, we achieve a meticulous extraction and in-depth exploration of thematic content, a methodological advancement in the field.

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  • * Researchers have developed innovative nanohybrids that can release oxygen while targeting and remodeling the tumor environment, enhancing the effectiveness of PDT/CDT.
  • * These nanohybrids show promising results in terms of targeted delivery, compatibility with blood and cells, and increased generation of reactive oxygen species, leading to improved cancer cell destruction.
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We consider the influence of different nanoparticles or micrometre-scale colloidal objects, which we commonly refer to as particles, on liquid crystalline (LC) orientational order in essentially spatially homogeneous particle-LC mixtures. We first illustrate the effects of coupling a single particle with the surrounding nematic molecular field. A particle could either act as a "dilution", i.

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In the realm of NH gas-sensing applications, the electrically conductive nature of TiCT MXene, adorned with surface terminations such as -O and -OH groups, renders it a compelling material. However, the inherent challenges of atmospheric instability and selectivity in the presence of gas mixtures have prompted the exploration of innovative solutions. This work introduces a strategic solution through the deposition of a mixed-matrix membrane (MMM) composed of poly(vinylidene fluoride) (PVDF) as the matrix and zeolitic imidazolate framework-67 (ZIF-67) as the filler.

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In this study, porous magnesium (Mg) scaffolds were investigated with varying strontium (Sr) and constant zinc (Zn) concentrations through the powder metallurgy process. All samples were examined at room temperature to evaluate their microstructure, mechanical anddegradation behaviour and biological properties. Results indicated that adding Sr was associated with fine average grain size, increased mechanical strength, and a decreased corrosion rate.

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The present work investigates the use of age-strengthened Mg-Zn-Mn-Ca/ZnO as resorbable materials in temporary orthopedic implants. Quaternary Mg-Zn-Mn-Ca alloy, reinforced with zinc oxide particles, was stir-cast, followed by solution treatment and a range of aging treatments. Optical and electron microscopy, mechanical, electrochemical, immersion, and dynamic mechanical testing, with biocompatibility assessment were carried out.

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The present work deals with the construction of a nanoscale system that can deliver chemotherapeutic agents to breast cancer cells in a controlled trend. The framework consists of gallic acid functionalized copper oxide nanoparticles (Ga@CuO) loaded with paclitaxel (PTX). To control the release of PTX, Ga@CuO NPs were coated with a red seaweed, Kappa carrageenan (K-carr) layer, and embellished with folic acid (FA) to enhance the targeted chemotherapy approach.

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Multifunctional nanoparticles for treatment in cancer are getting more and more attention recently. In this study, we employed a novel polydopamine (PDA) framework-based gold nanoparticles as a carrier of an antimetabolite drug, 5-Fluorouracil (5-FU). Folic acid (FA) was embellished onto the surface of nanoparticle imparting the nanosystem with remarkable tumor-targeting abilities through its precise binding with FA receptor that is notably overexpressed in breast cancer cells.

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  • Zinc is being researched as a biodegradable metal for implants due to its good compatibility with biological tissues but needs improvements in mechanical strength and cell viability.
  • This study developed a composite material (Zn-1Mg-1Cu-1ZrO) using stir-casting and enhanced its biocompatibility with a ceramic coating, showing promising mechanical properties and low corrosion and degradation rates.
  • The coated composite demonstrated higher cell viability and lower hemolysis compared to uncoated samples, indicating its potential as a suitable material for biodegradable implant applications.
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Worldwide, dyes are significant pollutants present in water because of their huge consumption for industrial purposes. These dyes as pollutants cause serious health issues in human beings and cause the loss of aquatic biodiversity. So, remediation of pollutants like dyes from wastewater is the need of the hour.

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  • Over 60% of India's population depends on agriculture, making it crucial for the economy, with rice husk being a common by-product of rice production.
  • For every five tonnes of rice harvested, one tonne of rice husk is produced, containing 40-60% silica and various other minerals.
  • This chapter focuses on developing carbon-based nanomaterials from rice husk, leveraging its high cellulose and lignin content as an economical carbon source.
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Macrophages engulf micron-sized objects including pathogens and cell debris by phagocytosis, serving a fundamental role in immune defense and homeostasis . Although the internalization process of suspended particles has been thoroughly investigated , it is incompletely understood how macrophages internalize surface-bound objects by overcoming the surface binding. Here, we prepared a force-sensing platform which visualizes cell-substrate adhesive force by fluorescence.

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In addition to their adjustable functionality, structural tunability, and compositional tunability, metal-organic frameworks (MOFs), often known as MOFs, are a distinct form of crystalline porous material. When reduced to two dimensions, ultrathin layers of MOF retain more of its fantastic external features, which is beneficial for a variety of technological applications. Due to their ultrathin atomic-level thickness, easily modifiable structure, and huge surface area, 2D MOF nanosheets and nanocomposites have been the subject of significant research.

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Bio-nanotechnology is one of the new and sound techniques that have various advantages over conventional methods of wastewater treatment. The utilization of nanomaterials like nanoparticles for wastewater treatment is emerging field of research. Both physical and chemical methods can be used for nanoparticle synthesis, but synthesis based on algae (biological method) has numerous advantages over others as it is environmentally friendly and sustainable.

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The present work aims to assess the age hardening of microalloyed Mg-Zn-Mn alloy reinforced with Ca(PO)(OH) (hydroxyapatite, HAp) particles to impart mechanical strength without deteriorating their degradation and biocompatibility behavior for their suitability toward resorbable fixation devices. The hydroxyapatite powder was synthesized with high purity. Mg-Zn-Mn (ZM31) and Mg-Zn-Mn/HAp (ZM31/HAp) were stir-cast, homogenized, and solution-treated to achieve uniform dissolution.

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Article Synopsis
  • * They have higher bioavailability compared to traditional zinc sources, improving poultry productivity and welfare while potentially lowering environmental impact.
  • * Despite these advantages, ZnO NPs can pose toxic risks depending on their size, shape, and concentration, necessitating further studies to understand their harmful effects and ensure safe use in dietary supplements.
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In this study, polyurethane (PU)-based xerogels were synthesized by using the biobased polyol derived from chaulmoogra seed oil. These polyol was used for the preparation of PU xerogels using methylene diphenyl diisocyanate hard segment and polyethylene glycol (PEG6000) as soft segment with 1,4-diazabicyclo[2, 2, 2]octane as catalyst. Tetrahydrofuran, acetonitrile and dimethyl sulfoxide were used as the solvents.

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