Effect of Hydroxychloroquine and Azithromycin Combination Use in COVID-19 Patients - An Umbrella Review.

Background: Hydroxychloroquine and Azithromycin combination was used rampantly in management of COVID-19 patients in different countries. Present review was conducted to evaluate the efficacy of Hydroxychloroquine and Azithromycin combination compared to the control (standard care) and any adverse effect following this combination use in COVID-19 patients if any.

Material And Methods: We included all the systematic review with or without meta-analysis reporting the effect of Hydroxychloroquine (HCQ) and Azithromycin (AZM) combination use in COVID-19 patient using three databases namely PubMed, medline, CINHAL, Web of Science from July 2020 till Jan 2022.

Machine learning approach to predict the biofuel production via biomass gasification and natural gas integrating to develop a low-carbon and environmental-friendly design: Thermodynamic-conceptual assessment.

A hybrid energy cycle (HEC) based on biomass gasification can be suggested as an efficient, modern and low-carbon energy power plant. In the current article, a thermodynamic-conceptual design of a HEC based on biomass and solar energies has been developed in order to generate electric power, heat and hydrogen energy. The planned HEC consists of six main units: two electric energy production units, a heat recovery unit (HRU), a hydrogen energy generation cycle based on water electrolysis, a thermal power generation unit (based on LFR field), and a biofuel production unit (based on biomass gasification process).

Optimization of a near-zero-emission energy system for the production of desalinated water and cooling using waste energy of fuel cells.

In the present study, a biomass-based multi-purpose energy system that can generate power, desalinated water, hydrogen, and ammonia is presented. The gasification cycle, gas turbine, Rankine cycle, PEM electrolyzer, ammonia production cycle using the Haber-Bosch process, and MSF water desalination cycle are the primary subsystems of this power plant. On the suggested system, a thorough thermodynamic and thermoeconomic evaluation has been conducted.

Simulation of CO capture from natural gas by cyclic pressure swing adsorption process using activated carbon.

This work presented modeling and simulation of CO from natural gas. One of the most promising technologies is Pressure Swing Adsorption (PSA), which is an energy-efficient and cost-effective process for separating and capturing CO from industrial processes and power plants. This paper provides an overview of the PSA process and its application for CO capture, along with a discussion of its advantages, limitations, and future research directions.

Investigations of microwave absorption performance of bi-layer absorber composed of FeWO & BiVO nanocomposite powder in 2-18 GHz.

Optimization necessitates every feature to be scrutinized associated with enhancement for microwave absorption. So, interplay between simulation and experiment is a significant aspect to find optimal findings in this regard. Herein, microwave absorption characteristics of as-prepared FeWO and BiVO nanomaterials were investigated by preparing mono layer and bilayer samples.

An Epidemiological Study on the Assessment of Cardiovascular Health Status among Adults in an Urban Area of Teliamura Municipality Area, Khowai, Tripura.

Background: In India, cardiovascular disease (CVD) is the largest cause of mortality and morbidity in all regions of the country. Now, to reduce the burden of CVD in our country, we first need to assess cardiovascular health status of the adult population.

Objective: The aim of this study is to assess cardiovascular health status among adults and to find the influence of sociodemographic factors on it.

A cross-sectional study on the prevalence of anxiety among school students in Teliamura municipality area of Tripura.

Background: Anxiety in adolescence has been a serious problem nowadays. It is seen that anxiety among students cause many harms to their mental and physical health affecting their career.

Objective: The objective of this study is to know about the burden of anxiety among school students and to find out the association of different grades of anxiety with sociodemographic characteristics and any other factors.

Knowledge, attitude, and practice regarding household consumption of iodized salt among rural women of Tripura, India: A mixed-methods study.

Introduction: Iodine is an essential element for thyroid function; it is necessary in minute amounts for normal growth, development, and well-being of all humans. There is gap in the utilization of adequately iodized salt in the rural areas due to nonavailability, poverty, poor knowledge of iodine deficiency diseases, and faulty storage practices.

Objective: The objective was to find out knowledge, attitude, and practices (KAP) regarding iodized salt consumption and association of sociodemographic factors, if any, among rural women of Tripura.

Awareness, treatment, and control of hypertension among adult population in a rural community of Singur block, Hooghly District, West Bengal.

Background: Hypertension is an important treatable public health problem both globally and in India with an increasing prevalence significantly in both urban and rural population. It is one of the leading causes of adult mortality and morbidity, but poorly controlled hypertension remains a major health problem.

Objective: The objective of this study was to find out awareness, treatment, and control of hypertension among study population and association of hypertension awareness with sociodemographic factors, if any.

An Epidemiological Study of Blood Pressure and Its Relation with Anthropometric Measurements among Schoolboys of Burdwan Municipal Area, West Bengal.

Background: High blood pressure (BP) is often an underdiagnosed problem, because of the asymptomatic nature in early phases of onset during adolescence. This increases the chances of developing complications later during adult life.

Objective: The objective of this study was to find the relationship of BP with anthropometric measurements among school-going adolescent boys.

Orcinol Glucoside Loaded Polymer - Lipid Hybrid Nanostructured Lipid Carriers: Potential Cytotoxic Agents against Gastric, Colon and Hepatoma Carcinoma Cell Lines.

Purpose: Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.

Methods: NLCs were prepared using tristearin, oleic acid and PEG-25/55-stearate by hot homogenization-ultrasonic dispersion; characterized by DLS, TEM, SEM, AFM, entrapment efficiency and drug loading capacity studies.

Paradoxical Bactericidal Effects of Hydrophobic Lung Surfactant Proteins and Their Peptide Mimics Using Liposome Molecular Trojan.

Lung surfactant, besides alveolar stability, also provides defence against pathogens by surfactant proteins (SP), SP-A and SP-D. The hydrophobic proteins SP-B and SP-C enhance surface activity. An unusual and paradoxical effect of bovine LS and synthetic model LS with SP-B/-C was bactericidal to Staphylococcus aureus and Escherichia coli.

Quality of life among geriatric population: A cross-sectional study in a rural area of Sepahijala District, Tripura.

Background: Quality of life (QOL) among elderly is an important area of concern which reflects the health status and well-being of this vulnerable population.

Objectives: The objective of this study is to find out different domains of QOL and its association with sociodemographic factors among geriatric population.

Methods:: A community-based cross-sectional study was done among 76 persons aged 60 years and above from August 2016 to October 2016 in rural areas of Madhupur, Sepahijala district, Tripura.

Effect of serum, cholesterol and low density lipoprotein on the functionality and structure of lung surfactant films.

Lung surfactant is a complex mixture of lipid and protein, responsible for alveolar stability, becomes dysfunctional due to alteration of its structure and function by leaked serum materials in disease. Serum proteins, cholesterol and low density lipoprotein (LDL) were studied with bovine lipid extract surfactant (BLES) using Langmuir films, and bilayer dispersions using Raman spectroscopy. While small amount of cholesterol (10 wt%) and LDL did not significantly affect the adsorption and surface tension lowering properties of BLES.

Physicochemical studies on the interaction of serum albumin with pulmonary surfactant extract in films and bulk bilayer phase.

Functionality, structure and composition of the adsorbed films of bovine lipid extract surfactant (BLES), in the absence and presence of bovine serum albumin (BSA), at the air-buffer interface was characterized through surface tension, atomic force microscopy and time of flight secondary ion mass spectrometric methods. Gel and fluid domains of BLES films were found to be altered significantly in the presence of BSA. Differential scanning calorimetric studies on BLES dispersions in presence of BSA revealed that the perturbations of the lipid bilayer structures were significant only at higher amount of BSA.

Molecular dynamics simulations of lung surfactant lipid monolayers.

Pulmonary surfactant provides for a lipid rich film at the lung air-water interface, which prevents alveolar collapse at the end of expiration. The films are likely enriched in the major surfactant component dipalmitoylphosphatidylcholine (DPPC), which, due to its saturated fatty acid chains, can withstand high surface pressures up to 70 mN/m, thereby reducing surface tension in that interface to very low values (close to 1 mN/m). Despite many experimental measurements in situ, as well as in vitro for native lung surfactant films, the exact mechanism by which other fluid lipid components of surfactant, in combination with surfactant proteins, allow for such low surface tension values to be reached is not well understood.

Interactions of serum with lung surfactant extract in the bronchiolar and alveolar airway models.

Lung surfactant (LS) a lipid-protein mixture is secreted by type-II pneumocytes and prevents alveolar collapse as well as maintains upper airway patency. In certain lung pathophysiology dysfunction of the LS occurs due to leakage of serum derived materials interacting with surfactant at the respiratory air-water interface. Bovine lipid extract surfactant (BLES) with and without foetal calf serum (FCS) were studied as models of bronchiolar airway patency using a capillary surfactometer, and in alveolar (terminal) airway using adsorbed Langmuir films in a surface balance.

Interfacial organizations of gel phospholipid and cholesterol in bovine lung surfactant films.

Pulmonary surfactants stabilize the lung by way of reducing surface tension at the air-lung interface of the alveolus. 31P NMR, thin-layer chromatography, and electrospray ionization mass spectroscopy of bovine lipid extract surfactant (BLES) confirmed dipalmitoylphosphatidylcholine (DPPC) to be the major phospholipid species, with significant amounts of palmitoyl-oleoylphosphatidylcholine, palmitoyl-myristoylphosphatidylcholine, and palmitoyl-oleoylphosphatidylglycerol. BLES and DPPC spread at the air-water interface were studied through surface pressure area, fluorescence, and Brewster angle microscopy measurements.

An X-ray diffraction study of alterations in bovine lung surfactant bilayer structures induced by albumin.

Lung surfactant (LS) is an extra-cellular lipid-protein system responsible for maintaining low surface tension in the lung and alveolar stability. Serum proteins cause dysfunction of this material, e.g.

Probing perturbation of bovine lung surfactant extracts by albumin using DSC and 2H-NMR.

Lung surfactant (LS), a lipid-protein mixture, forms films at the lung air-water interface and prevents alveolar collapse at end expiration. In lung disease and injury, the surface activity of LS is inhibited by leakage of serum proteins such as albumin into the alveolar hypophase. Multilamellar vesicular dispersions of a clinically used replacement, bovine lipid extract surfactant (BLES), to which (2% by weight) chain-perdeuterated dipalmitoylphosphatidycholine (DPPG mixtures-d(62)) had been added, were studied using deuterium-NMR spectroscopy ((2)H-NMR) and differential scanning calorimetry (DSC).

Pulmonary surfactant function is abolished by an elevated proportion of cholesterol.

A molecular film of pulmonary surfactant strongly reduces the surface tension of the lung epithelium-air interface. Human pulmonary surfactant contains 5-10% cholesterol by mass, among other lipids and surfactant specific proteins. An elevated proportion of cholesterol is found in surfactant, recovered from acutely injured lungs (ALI).

Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals.

Pulmonary surfactant, a complex mixture of lipids and proteins, lowers the surface tension in terminal air spaces and is crucial for lung function. Within an animal species, surfactant composition can be influenced by development, disease, respiratory rate, and/or body temperature. Here, we analyzed the composition of surfactant in three heterothermic mammals (dunnart, bat, squirrel), displaying different torpor patterns, to determine: 1) whether increases in surfactant cholesterol (Chol) and phospholipid (PL) saturation occur during long-term torpor in squirrels, as in bats and dunnarts; 2) whether surfactant proteins change during torpor; and 3) whether PL molecular species (molsp) composition is altered.

Disparate effects of two phosphatidylcholine binding proteins, C-reactive protein and surfactant protein A, on pulmonary surfactant structure and function.

C-reactive protein (CRP) and surfactant protein A (SP-A) are phosphatidylcholine (PC) binding proteins that function in the innate host defense system. We examined the effects of CRP and SP-A on the surface activity of bovine lipid extract surfactant (BLES), a clinically applied modified natural surfactant. CRP inhibited BLES adsorption to form a surface-active film and the film's ability to lower surface tension (gamma) to low values near 0 mN/m during surface area reduction.

Effect of acute lung injury on structure and function of pulmonary surfactant films.

The structural and functional alterations in pulmonary surfactant that occur during acute lung injury were studied using rat lung surfactant large aggregates (LA) isolated from normal nonventilated lungs (N), and from standard ventilated (V) and injuriously ventilated (IV) excised lungs. N lungs inflated significantly better than IV lungs, with V lungs intermediate. Although IV LA phosphatidylcholine levels were unchanged, cholesterol and protein were elevated.