A biocompatible Ni(II) complex as an amyloid sensor for human PrP fibrillar aggregates.

KRS-1, a biocompatible nickel(II) complex, is introduced as a potent fluorescent probe for PrP fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP aggregation. Fluorescence microscopy confirms its efficacy in identifying PrP fibrillar aggregates in HT-22 cells.

Biodegradable cellulose nanocrystal composites doped with carbon dots for packaging and anticounterfeiting applications.

Developing sustainable and multifunctional materials is imperative for advancing anti-counterfeiting measures, sensing technologies, and intelligent packaging solutions. Concurrently, materials based on carbon dots (CDs) and cellulose nanocrystals (CNCs) are becoming established in such applications. Therefore, herein, we present the fabrication and characterization of water-based CDs and CNCs from (black lentil: BL).

Organometallic Ru(III) Catalysts for α-Alkylation of Carbonyl Compounds using Alcohols: Mechanistic Insights via Detection of Key Intermediates.

Three novel cyclometalated ruthenium complexes ([Ru.L] [Ru.L] and [Ru.

Scrub Typhus and Bilateral Lateral Rectus Palsy: An Uncommon Manifestation.

Scrub typhus is a zoonotic disease that typically presents as an acute febrile illness. It is caused by the rickettsial organism , which is prevalent in the Asian region. The clinical manifestations of scrub typhus can vary significantly, ranging from mild febrile illness to severe multiorgan dysfunction syndrome.

Well Defined Phosphine Free Ni-Catalyzed Dehydrogenation of Secondary Alcohols for the Synthesis of Ketones and Ketazines.

In this work, we unveil a novel synthesis of bench stable Ni (II) complexes supported by tetradentate Schiff-base ligands and the complexes were devoid of any phosphine or phosphine-based ligand. These Ni-complexes were successfully applied for the dehydrogenation of secondary alcohols for ketone and ketazine syntheses. Secondary alcohols with different functional groups were well tolerated during catalytic cycle.

A multi-component synthetic route for 2-pyrazolines acceptorless dehydrogenation of alcohols using homogeneous Ni(II) catalysts.

Herein, we present the first efficient and sustainable multicomponent synthesis (MCS) of 2-pyrazolines using acceptorless dehydrogenation of benzyl alcohols catalysed by nickel(II) catalysts. Two air-stable phosphine free nickel(II) complexes anchored by NNN-type pincer ligands were synthesized and efficiently used in the MCS of 40 distinct pyrazoline derivatives.

Solvent-Selective Fluorescence Sensing of Mg and Al Ions by Pincer-Type NNO Schiff Base Ligand: An Experimental and DFT Optimized Approach.

A newly developed dual-functional fluorescence sensing probe (phenylhydrazinyl pyridine) Schiff base (SB) has been designed with good selectivity for distinguishing Mg and Al metal ions in different solvent solutions. SB exhibits quick and visual turn-on fluorescence enhancement in response to Mg and Al detection. The addition of Mg in ACN-HEPES buffer (1 : 1, v/v, pH 7.

Harvesting Green Hydrogen from the Deep Blue: Seawater-Compatible SnSe-P Decorated Graphene-CNTs Based Electrocatalyst Under Universal pH.

Fabrication of cost-effective and robust metal-based electrocatalysts for hydrogen evolution reactions (HER) across the entire pH range has garnered significant attention in harvesting renewable energy. Herein, the fabrication of 3D high-surface Ni Foam-Graphene-Carbon Nanotubes (NGC) decorated with phosphorous-inserted tin selenide (SnSe-P) showcases unprecedented HER activity with minimal overpotentials across all pH ranges (52 mV in acidic, 93 mV in basic, and 198 mV in neutral conditions@10 mA cm) and stability at 1 A cm for 72 h. The as-designed catalyst shows a low overpotential of 122 mV@10 mA cm in alkaline seawater, achieved through controlled electronic distribution on Sn site after incorporation of P in NGC-SnSe-P.

Medical visits and mortality among dementia patients during the COVID-19 pandemic compared to rates predicted from 2019.

Background: During the COVID-19 pandemic, patients with Alzheimer's disease and related dementias (ADRD) were especially vulnerable, and modes of medical care delivery shifted rapidly. This study assessed the impact of the pandemic on care for people with ADRD, examining the use of primary, emergency, and long-term care, as well as deaths due to COVID and to other causes.

Methods: Among 4.

Transition Metal Complexes as Therapeutics: A New Frontier in Combatting Neurodegenerative Disorders through Protein Aggregation Modulation.

Neurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively impair the protein structure and result in neurological dysfunction in the nervous system. Among these disorders, Alzheimer's disease (AD), prion diseases such as Creutzfeldt-Jakob disease (CJD), and Parkinson's disease (PD) are caused by protein misfolding and aggregation at the cellular level. In recent years, transition metal complexes have gained significant attention for their potential applications in diagnosing, imaging, and curing these NDDs.

A Splenic Infarct in Scrub Typhus: A Rare Entity.

Scrub typhus is a zoonotic feverish condition that can range from mild to severe, potentially life-threatening symptoms. Common signs include fever, headache, muscle pain, and a skin rash. Although rare, splenic infarction is a known complication of scrub typhus, with only a limited number of cases documented in medical literature.

One-Pot Synthesis of 1, 2-Dihydro [1,2,4] Triazinium Salt by Copper-Assisted Unprecedented Cyclization Reaction: Applications in DNA and Protein Interaction Studies.

Copper catalyzed intramolecular annulation of 2-((2-benzylidene-1-phenylhydrazineyl)methyl)pyridine derivatives was described. It was found that Cu(II) is reduced under the reaction condition to Cu(I). Synthesized 1,2-dihydro [1,2,4] triazinium salt showed fluorescence activity in the solid state.

Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3-1,2,4-triazole-3-thione.

Galectin-3 (Gal-3) is a carbohydrate binding protein that has been implicated in the development and progression of fibrotic diseases. Proof-of-principal animal models have demonstrated that inhibition of Gal-3 is a potentially viable pathway for the treatment of fibrosis─with small molecule Gal-3 inhibitors advanced into clinical trials. We hereby report the discovery of novel galactose-based monosaccharide Gal-3 inhibitors comprising 2-methyl-4-phenyl-2,4-dihydro-3-1,2,4-triazole-3-thione (compound ) and 4-phenyl-4-1,2,4-triazole (compound ).

Sculpting liquid metal stabilized interfaces: a gateway to liquid electronics.

Liquid electronics have potential applications in soft robotics, printed electronics, and healable electronics. The intrinsic shortcomings of solid-state electronics can be offset by liquid conductors. Alloys of gallium have emerged as transformative materials for liquid electronics owing to their intrinsic fluidity, conductivity, and low toxicity.

Modulating the aggregation of human prion protein PrP by an indole-based cyclometallated palladium complex.

The spontaneous aggregation of infectious or misfolded forms of prion protein is known to be responsible for neurotoxicity in brain cells, which ultimately leads to the progression of prion disorders. Bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease (CJD) in humans are glaring examples in this regard. Square-planar complexes with labile ligands and indole-based compounds are found to be efficiently inhibitory against protein aggregation.

Harnessing Environmental Sensitivity in SnSe-Based Metal-Semiconductor-Metal Devices: Unveiling Negative Photoconductivity for Enhanced Photodetector Performance and Humidity Sensing.

The extreme sensitivity of 2D-layered materials to environmental adsorbates, which is typically seen as a challenge, is harnessed in this study to fine-tune the material properties. This work investigates the impact of environmental adsorbates on electrical properties by studying metal-semiconductor-metal (MSM) devices fabricated on CVD-synthesized SnSe flakes. The freshly prepared devices exhibit positive photoconductivity (PPC), whereas they gradually develop negative photoconductivity (NPC) after being exposed to an ambient environment for ∼1 day.

A sustainable strategic approach for -alkylation of amines with activation of alcohols triggered a hydrogen auto-transfer reaction using a Pd(II) complex: evidence for metal-ligand cooperativity.

This work describes a new well-defined, air-stable, phosphine free palladium(II) [Pd(L)Cl] (1) catalyst. This catalyst was utilized for -alkylation of amines and indole synthesis where HO was found to be the by-product. A broad range of aromatic amines were alkylated using this homogeneous catalyst with a catalyst loading of 0.

Short term biodistribution and in vivo toxicity assessment of intravenously injected pristine graphene oxide nanoflakes in SD rats.

The present study aimed to elucidate the short term biodistribution of nano sized graphene oxide (GO) along with the toxicological assessment under condition with an intent to analyse the toxic effects of sudden accidental exposure of GO The synthesised GO was characterized using UV-Visible spectroscopy, XRD, FTIR, Raman spectroscopy, TGA and DLS. The morphological imaging was performed using SEM, TEM and AFM. With a lateral size of less than 300 nm, these nanoparticles exhibit significant organ barrier permeability of up to 20%.

A rare case of multifocal craniospinal leptomeningeal melanocytoma: A case report and scoping review.

Introduction: Leptomeningeal melanocytomas are rare tumours originating from neural crest derived melanocytes. They are usually solitary and presentation with multifocal meningeal melanocytoma is very rare and indicative of potentially more aggressive behaviour. This case report and scoping review sought to evaluate the presentation, and key radiological features that can help differentiate multifocal meningeal melanocytoma from other differentials and provide a discussion of the key management and prognostic points once these tumours are diagnosed.

Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.

As a result of our continued efforts to pursue Gal-3 inhibitors that could be used to fully evaluate the potential of Gal-3 as a therapeutic target, two novel series of benzothiazole derived monosaccharides as potent (against both human and mouse Gal-3) and orally bioavailable Gal-3 inhibitors, represented by 4 and 5, respectively, were identified. These discoveries were made based on proposals that the benzothiazole sulfur atom could interact with the carbonyl oxygen of G182/G196 in h/mGal-3, and that the anomeric triazole moiety could be modified into an N-methyl carboxamide functionality. The interaction between the benzothiazole sulfur and the carbonyl oxygen of G196 in mGal-3 was confirmed by an X-ray co-crystal structure of early lead 9, providing a rare example of using a S···O binding interaction for drug design.

Catalytic, Antifungal, and Antiproliferative Activity Studies of a New Family of Mononuclear [VO]/[VO] Complexes.

Ligands derived from 2-(1-phenylhydrazinyl)pyridine and salicylaldehyde (HL), 3-methoxysalicylaldehyde (HL), 5-bromosalicylaldehyde (HL), and 3,5-di--butylsalicylaldehyde (HL) react with [VO(acac)] in MeOH followed by aerial oxidation to give [VO(L)] (), [VO(L)] (), [VO(L)] (), and [VO(L)] (). Complex [VO(acac)(L)] () is also isolable from [VO(acac)] and HL in dry MeOH. Structures of all complexes were confirmed by single-crystal X-ray and spectroscopic studies.

Phosphorus-Doped Nickel Oxide Micro-Supercapacitor: Unleashing the Power of Energy Storage for Miniaturized Electronic Devices.

For an uninterrupted self-powered network, the requirement of miniaturized energy storage device is of utmost importance. This study explores the potential utilization of phosphorus-doped nickel oxide (P-NiO) to design highly efficient durable micro-supercapacitors. The introduction of P as a dopant serves to enhance the electrical conductivity of bare NiO, leading to 11-fold augmentation in volumetric capacitance to 841.

Crystal structure of a phenoxyl radical complex relevant to the metal site of the galactose oxidase enzyme: A facile one-pot synthesis, evidence for hydrogen atom transfer and DNA cleavage self-activation.

Copper complexes [Cu(LH)ClO] (1) and [Cu(L)NO] (2), which are relevant to the metal site of the galactose oxidase enzyme, were synthesized and characterized by different spectroscopic methods. LH and LH [where LH stands for 2,2'-((1,1')(2,2'-(pyridine-2,6-diyl)bis(2-phenylhydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol and LH stands for 6,6'-((1,1')-(2,2'-(pyridine-2,6-diyl)bis(2-phenylhydrazin-2-yl-1-ylidene))bis(methanylylidene))bis(2,4-di--butylphenol), H stands for dissociable proton] are pentadentate ligands. These ligands provide pyridyl N, two imine N, and two non-innocent phenoxyl and phenolato O donors, forming complex 1 as a non-radical complex, while complex 2 is a phenoxyl radical complex.