Impact of feeding Murraya koenigii and Aegle marmelos leaves on metabolic and reproductive performance in crossbred cows.

The study was carried out to ascertain the effect of feeding herbal formulation (A. marmelos and M. koenigii) on metabolic profile and reproductive performance of crossbred cows.

Low dose ondansetron with dexamethasone for prophylaxis of postoperative nausea and vomiting following laparoscopic cholecystectomy-A randomized double-blind study.

Background And Aims: Ondansetron and dexamethasone combination is effective for prophylaxis against postoperative nausea and vomiting (PONV). Ondansetron, when compared to dexamethasone, is known to cause more adverse effects and is relatively expensive. The present study evaluated the efficacy of standard dose and low dose ondansetron, i.

Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing.

Pharmaceutical pollution in wastewater poses significant environmental and public health concerns worldwide. Chloramphenicol (CP), an antibiotic widely used in medical and veterinary applications, is among the active pharmaceutical ingredients (APIs) frequently detected in aquatic environments. This study explored the encapsulation of chloramphenicol API in contaminated wastewater using rationally designed fibrations based on the silver metal ion-directed self-assembly of fibrillator-type self-assembling ligand ().

Design of BBB permeable BACE-1 inhibitor as potential drug candidate for Alzheimer disease: 2D-QSAR, molecular docking, ADMET, molecular dynamics, MMGBSA.

BACE-1 is a prime therapeutic target for treatment of Alzheimer disease as it cleaves the β-site of APP leading to formation of amyloid plaques. A dataset of 229 benzo-fused heterocyclic compounds reported as BACE-1 inhibitors was utilized to develop various QSAR models (regression and classification) utilizing Monte Carlo algorithm. The dataset was randomly split into different sets for generation of models.

Securing the 6G-IoT Environment: A Framework for Enhancing Transparency in Artificial Intelligence Decision-Making Through Explainable Artificial Intelligence.

Wireless communication advancements have significantly improved connectivity and user experience with each generation. The recent release of the framework M.2160 for the upcoming sixth generation (6G or IMT-2030) cellular wireless standard by ITU-R has significantly heightened expectations, particularly for Internet of Things (IoT) driven use cases.

Lipid Nanocarriers as Precision Delivery Systems for Brain Tumors.

Brain tumors, particularly glioblastomas, represent the most complicated cancers to treat and manage due to their highly invasive nature and the protective barriers of the brain, including the blood-brain barrier (BBB). The efficacy of currently available treatments, viz., radiotherapy, chemotherapy, and immunotherapy, are frequently limited by major side effects, drug resistance, and restricted drug penetration into the brain.

An exploratory SWATH plasma proteomics analysis of phyllodes tumor- a type of female breast tumor.

Objective: Phyllodes tumors (PT) are rare fibroepithelial breast tumors with poorly understood molecular pathology. This study intent to identify the potential plasma markers of phyllodes tumors compared to controls using Sequential window acquisition of all theoretical fragment ion spectra-mass spectrometry (SWATH-LC-MS) based proteomics approach.

Method: Plasma samples from phyllodes tumor cases and controls underwent SWATH-LC-MS/MS based untargeted proteomics analysis.

Acute Myocarditis in the Setting of Plasmodium vivax Malaria: A Case Report and Review of the Literature.

Plasmodium vivax (P. vivax) malaria is typically considered a benign form of malaria, with fewer life-threatening complications compared with Plasmodium falciparum. However, emerging evidence suggests that P.

Forecasting the seasonal phenology of in Oregon grass seed and vegetable agroecosystems.

(Lepidoptera: Noctuidae) is a significant pest in Oregon grass seed and vegetable production systems. Effective management of this species relies on timely foliar insecticide applications targeting immature larvae before crop damage is observed. Regionally specific phenological models serve as a critical component of effective areawide pest management plans to inform the timing of pest monitoring and management action.

Functional Nanofibres of Tb(III)-Coupled Metal-Organic Gel: Detection To Decontamination of Thiabendazole In Environmental Samples.

Pollutant residues such as pharmaceuticals or pesticides in water bodies pose significant environmental and health risks, necessitating the development of advanced sensing and removal techniques to ensure safe and sustainable water resources. Tb-based luminescent sensors offer high sensitivity for pollutant residue analysis, but their application is often limited to detection. Developing Tb-derived metal-organic gel (ANS-4G-Tb) as soft supramolecular material is proposed to enhance trace contamination removal, integrating both sensing and sequestration capabilities.

A Comprehensive Review of Psychosocial, Academic, and Psychological Issues Faced by University Students in India.

Background: University students confront a wide range of issues during their pursuit of education. Understanding these issues is essential for developing effective treatments and support systems.

Purpose: This study aims to delineate the landscape of scholarly literature pertaining to psychosocial, academic, and psychological issues among university students.

Anionic lipid catalyzes the generation of cytotoxic insulin oligomers.

Misfolding and aggregation of proteins into amyloidogenic assemblies are key features of several metabolic and neurodegenerative diseases. Human insulin has long been known to form amyloid fibrils under various conditions, which affects its bioavailability and function. Clinically, insulin aggregation at recurrent injection sites poses a challenge for diabetic patients who rely on insulin therapy.

Sustainable corrosion prevention of mild steel in acidic media with herb extract.

Mild steel provides strength to various building and industrial materials but it is badly affected by corrosion. In the present study, we investigate the efficacy of , a plant-based green corrosion inhibitor to minimize mild steel corrosion in a 1 M HSO solution. Weight loss, surface coverage, inhibition efficiency, and corrosion rate measurements were evaluated for various inhibitor concentrations and time intervals.

Pyrene functionalized organic cation receptor-based "turn-on" fluorescence approach for monitoring of chlorpyrifos in food, soil, and water samples.

Background: The unregulated use of pesticides by farmers, for crop productivity results in widespread contamination of organophosphates in real environmental samples, which is a growing societal concern about their potential health effects. The conventional approaches for the monitoring these organophosphate-based pesticides which include immunoassays, electrochemical methods, immunosensors, various chromatography techniques, along with some spectroscopic methods, are either costly, sophisticated, or involves the use of different metal complexes. Therefore, there is an urgent need for sensitive, quick, and easy-to-use detection techniques for the screening of widely used organophosphate-based pesticides.

Surface Engineered Nanoparticles Coupled with Pattern Recognition Techniques for Rapid Identification and Discrimination of Multiple Thiols in a Real Sample Matrix.

Thiols, including Cysteine (CYS) and Glutathione (GSH), play pivotal roles in numerous physiological processes as they are integral components of many essential biomolecules and are found abundantly in foods such as additives and antioxidants. Any deviations in thiol concentrations can disrupt normal physiological functions, affecting the body's metabolism and potentially leading to diseases such as Alzheimer's and Parkinson's diseases, etc. Consequently, the imperative need for developing reliable and robust techniques for thiol analysis is crucial for early disease detection and ensuring food safety.

A Randomized Controlled Trial of Medial Prefrontal Cortex Theta Burst Stimulation for Cocaine Use Disorder: A Three-Month Feasibility and Brain Target Engagement Study.

Background: Cue-induced craving precipitates relapse in drug and alcohol use disorders. Theta burst stimulation (TBS) to the left frontal pole of the medial prefrontal cortex (MPFC) has previously been shown to reduce drinking and brain reactivity to alcohol cues. In this randomized, double-blind, sham-controlled target engagement study, we aimed to assess whether TBS has similar effects in individuals with cocaine use disorder.

Behavioral Management in the Rehabilitation of a Person with Severe Mental Illness: The Path Less Travelled.

In severe mental illness (SMI), such as schizophrenia, rehabilitation begins immediately. Aside from the token economy, there is limited literature on behavioral modification (BM), which is a crucial aspect of rehabilitation for person with severe mental illness (SMI). We demonstrate the implementation and effectiveness of BM for one year in managing behavioral difficulties in a person with SMI.

Role of Microsurgery in Organ-Preserving Surgeries in Uro-oncology.

Organ preservation surgery is the need of the hour in cancer management whenever it is feasible. Vascular continuity is a must for organ preservation. We found such same in this article.

Expression of Immune Checkpoint Regulator Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) and Programmed Cell Death Protein Ligand 1 (PD-L1) in Invasive Ductal Carcinoma Breast.

Despite significant advancement in the diagnostic and therapeutic aspects of breast carcinoma, the prognosis remains dismal. Recently, with advances in its understanding, various immune system-based management strategies have been developed. CTLA-4 suppresses lymphocyte reactivity, IL-2 secretion, and IL-2 receptor expression and triggers cell cycle arrest.

Comparative metabolomics-based screening of fruit extracts of less-known melon ( var accessions collected from dry terrain of North India by using HPLC-DAD.

(Naudin) is an important wild crop that belongs to the family Cucurbitaceae. Fruits possess digestive, stomachic, vermifuge and febrifuge properties and possess analgesic, antioxidant, antibacterial and anti-inflammatory activities. Current research is aimed at screening diverse phytoconstituents present in the fruit extract of wild melon ( var.

Machine learning driven metal oxide-based portable sensor array for on-site detection and discrimination of mycotoxins in corn sample.

Cereals, grains, and feedstuffs are prone to contamination by fungi during various stages from growth to storage. These fungi may produce harmful mycotoxins impacting food quality and safety. Thus, the development of quick and reliable methods for on-site application is crucial for ensuring food safety and quality monitoring.

A physiotherapists perspective of a geriatric clinic in a tertiary oncology centre.

Aims And Objectives: To analyse various domains amongst the geriatric population such as age, gender, body mass index (BMI), comorbidities, type of cancer and use of assistive devices, and find a correlation between the outcome measures such as short physical performance battery (SPPB) and performance-oriented mobility assessment (POMA).

Methodology: Patients above 60 years were screened and further referred to the physiotherapy department. A brief history was recorded to retrieve the demographic data such as name, age, gender, height, weight, BMI, hand dominance, diagnosis, previous investigations are done, comorbidities if any present, use of assistive devices if required and in case any previous oncological treatment has been delivered.