Primary anaplastic extramedullary plasmacytoma in the lacrimal sac.

We report the case of a 60-year-old man diagnosed with unilateral, solitary, extramedullary plasmacytoma located in the right lacrimal sac fossa, with no systemic involvement. This rare plasma cell dyscrasia is usually found in the respiratory tract. Clinical and radiological features of the mass and histopathological results are described.

Do US quitsites present information related to providing services for LGBTQ individuals? An audit study.

Introduction: Most US quitlines have quitsites and websites designated to promote their services. Quitsites have the potential to encourage LGBTQ individuals to utilize quitline services by explicitly mentioning the provision of LGBTQ-competent services. The present study audited quitsites to determine the presence of information regarding services for LGBTQ individuals.

Pulmonary thromboembolism presenting with hoarseness of voice.

A young man in his late 30s with a history of pulmonary tuberculosis presented with complaints of hoarseness of voice persisting for 6 months. Chest auscultation revealed diminished breath sounds over the right lung field. An initial chest X-ray showed collapse of the right lung with mediastinal shift towards right.

Phakic corneal decompensation with cataract after bioptics: management challenges.

A woman in her early 50s presented with diminution of vision, photophobia, pain and watering in right eye for 8 months. She had previously undergone radial keratotomy (RK) in the right eye, followed by bilateral angle-supported phakic intraocular lens (pIOL) implantation. On examination, 16 RK incisions were present in the right eye, with corneal decompensation, rigid angle-supported pIOL in situ, senile cataract and uncorrected distance visual acuity (UDVA) of counting fingers.

Decarboxylative click cycloaddition: an emerging strategy towards substituted 1,2,3-triazole derivatives.

1,2,3-triazole is a vital structural motif of various drugs and therapeutic leads, as well as a linker for bioconjugation and molecular recognition. Cu-catalysed click cycloaddition of azides with terminal alkynes (CuAAc) is an important reaction to construct the triazole core. In recent years, various decarboxylative click strategies utilizing alkynoic acids as stable surrogates for low boiling or gaseous alkynes have been developed.

Modulation of gut microbiome in response to the combination of Nissle 1917 and sugars: a pilot study using host-free system reflecting impact on interpersonal microbiome.

Introduction: The differential effects of probiotic, prebiotic, and synbiotic formulations on human health are dictated by the inter-individual gut microbial profile. The effects of probiotics such as Nissle 1917 (ECN) on gut microbiota may vary according to the microbiome profiles of individuals and may be influenced by the presence of certain carbohydrates, which can impact microbial community structure and treatment results.

Method: Processed fecal samples from donors having contrasting lifestyles, dietary patterns, and disease histories were mixed with 5 × 10 CFU/mL ECN with or without 1% (w/v) sugars (glucose, galactose, or rice starch) in a host-free system.

Stretchable hierarchical metal wire networks for neuromorphic emulation of nociception and anti-nociception.

Among biomimetic technologies, the incorporation of sensory hardware holds exceptional utility in human-machine interfacing. In this context, devices receptive to nociception and emulating antinociception gain significance as part of pain management. Here we report, a stretchable two-terminal resistive neuromorphic device consisting of a hierarchical Ag microwire network formed using a crack templating protocol.

A potential role of gut microbiota in stroke: mechanisms, therapeutic strategies and future prospective.

Rationale: Neurological conditions like Stroke and Alzheimer's disease (AD) often include inflammatory responses in the nervous system. Stroke, linked to high disability and mortality rates, poses challenges related to organ-related complications. Recent focus on understanding the pathophysiology of ischemic stroke includes aspects like cellular excitotoxicity, oxidative stress, cell death mechanisms, and neuroinflammation.

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome.

Lasso peptides, biologically active molecules with a distinct structurally constrained knotted fold, are natural products belonging to the class of ribosomally-synthesized and posttranslationally modified peptides (RiPPs). Lasso peptides act upon several bacterial targets, but none have been reported to inhibit the ribosome, one of the main antibiotic targets in the bacterial cell. Here, we report the identification and characterization of the lasso peptide antibiotic, lariocidin (LAR), and its internally cyclized derivative, lariocidin B (LAR-B), produced by .

Long-Term Assessment of PC-IOL Optic Apposition in Surface-Modified IOL and Its Impact on Nd:YAG Capsulotomy Rate and Visual Quality.

Purpose: To assess apposition of posterior capsule (PC) to intraocular lens (IOL) optic in ultraviolet (UV)/ozone surface modified IOL and its impact on neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy rate and visual quality.

Design: Prospective interventional case series.

Methods: The study enrolled 100 eyes implanted with UV/ozone surface modified hydrophobic acrylic IOL during phacoemulsification.

Current paradigms in refractive surgery.

Refractive surgeries have evolved from the archaic incisional corneal procedures to the use of sophisticated femtosecond lasers and new-generation phakic intraocular lenses (pIOL) for surgical correction of refractive errors. The armamentarium of modern-day refractive surgery includes corneal-based procedures such as photorefractive keratectomy, laser-assisted in situ keratomileusis and keratorefractive lenticule extraction, as well as lensbased pIOL implantation. The current procedures are associated with a high index of efficacy and predictability, with enhanced safety and a significant reduction in sight-threatening complications.

Decrypting Skin Microbiome in Psoriasis: Current Status.

Background: Psoriasis is an autoimmune, chronic, inflammatory skin condition of multifactorial etiology. Recent studies in human skin microbiome research have revealed the dysbiosis in lesional skin of psoriatic patients, as well as have established the association of dysbiosis in the elicitation of inflammatory response of psoriatic skin.

Objective: The present review aimed to recapitulate the insights of psoriasis lesional skin microbiome studies published in the last 2 decades, and to determine the most important bacterial genera that can be deployed as psoriatic skin microbial signature for therapeutic intervention.

Identification of critical amino acids in the DNA binding domain of LuxO: Lessons from a constitutive active LuxO.

Quorum sensing plays a vital role in the environmental and host life cycles of Vibrio cholerae. The quorum-sensing circuit involves the consorted action of autoinducers, small RNAs, and regulatory proteins to control a plethora of physiological events in this bacterium. Among the regulatory proteins, LuxO is considered a low-cell-density master regulator.

Cloning, Overexpression and Application of Lipase from Thermotolerant TTP-06 in the Degradation of Polyhydroxyalkanoate.

Unlabelled: Polyhydroxyalkanoates (PHAs) constitute a principal group of bio-degradable polymers that are produced by certain microbes under limited supply of nutrients. PHA is a linear polyester that comprises of 3-hydroxy fatty acid monomers. Triacylglycerol acylhydrolases are known to catalyze the hydrolysis of ester linkages and in turn they are beneficial in the degradation of PHA.