Turn-off fluorescent magnetic Mn-ZnS molecularly imprinted probe for the detection of chlorpyrifos in vegetable samples.

A sensitive and efficient fluorescent sensor based on a magnetic manganese-doped zinc sulfide molecularly imprinted probe (FeO/Mn-ZnS/MIP) was successfully developed for the detection of chlorpyrifos (CPF). The probe combined the advantages of magnetic separation, the fluorescence properties of Mn-ZnS, and the exceptional molecule recognition capabilities of molecularly imprinted polymers. The developed sensor exhibits selective binding to CPF, resulting in a quenching of fluorescence intensity of FeO/Mn-ZnS/MIP by a photo-induced electron transfer mechanism.

Correlation between conventional karyotype, interphase FISH and immunophenotype in risk stratification of newly diagnosed plasma cell myeloma: An observational study.

Background: Plasma cell myeloma (PCM) is a common adult hematological neoplasm of terminally differentiated B-cells resulting in accumulation of monoclonal plasma cells. PCM is heterogeneous disease with survival time varies from months to years, determined by age, stage, cytogenetics abnormalities, and treatment response. There is conflicting evidence in role of immunophenotype as a prognostic indicator.

Innovative approaches to cationic and anionic (catanionic) amphiphiles self-assemblies: Synthesis, properties, and industrial applications.

Meeting the contemporary demand for the development of functional, biocompatible, and environment friendly self-assembled structures using efficient, cost-effective, and energy-saving methods, the field of colloids has witnessed a surge in interest. Research into cationic and anionic (catanionic) surfactant combinations has gained momentum due to their distinct advantages and synergistic properties in this context. Catanionic self-assemblies have emerged as promising contenders for addressing these requirements.

Long-chain perfluoro carboxylic acids in landfill leachate: Extraction, detection and biodegradation.

Landfills serve as major repositories for products containing per- and polyfluoroalkyl substances (PFASs). These compounds have been documented in the resulting leachate, posing a significant threat to both surface water and groundwater quality. Long-chain perfluoro carboxylic acids (LC-PFCAs), which act as precursors to shorter-chain PFCAs, are particularly persistent in the environment.

Invasive Arterial BP Measurements in the Emergency Department-When, if Ever, is it Indicated?

Purpose Of Review: Extremes of blood pressure (BP) are common among patients that visit emergency departments. In this review article, we discuss the specific indications for invasive blood pressure monitoring in the ED, particularly in the context of undifferentiated shock and hypertensive emergencies.

Recent Findings: In most cases, non-invasive techniques suffice for blood pressure monitoring, however, in certain patient presentations intermittent automated oscillometry bears significant drawbacks.

Tumor Control and Normal Tissue Complications in High-dose-rate Brachytherapy for Cervical Cancer Patients Using Ir-192 Radioactive Source.

Introduction: The purpose of the study was to calculate, tumor control probability (TCP) and normal tissue complication probability (NTCP) in cervical cancer patients and to clinically correlate the outcomes with a follow-up period of 24 months.

Materials And Methods: One hundred and fifty patients were included in the present study who received 46 Gy/23 fractions/4½ weeks of external beam radiotherapy with concurrent cisplatin chemotherapy, followed by intracavitary brachytherapy of 3 different fractionations regimens, i.e.

High-performance, high energy density symmetric supercapacitors based on δ-MnO nanoflower electrodes incorporated with an ion-conducting polymer.

The present work investigates liquid-based and liquid-free supercapacitors assembled using δ-MnO-nanoflower-based electrodes. An optimized electrode composition was prepared using acetylene black (AB), a polymer (PEO), a salt (LiClO), and δ-MnO and used for device fabrication. The composite electrode was tested against a liquid electrolyte and a 'liquid-free' composite solid polymer electrolyte (CSPE) membrane.

Barriers and Facilitators of Management of Type-1 Diabetes in Children: A Socio-Cultural Enquiry of Caregivers' Perspectives Living in Resource-Constrained Settings.

Purpose: Caregivers are key stakeholders in management of children with Type 1 Diabetes (T1D), but their perspectives have remained understudied, especially in the developing countries. This study explores their perspectives on the barriers and facilitators of management of a child with T1D in a resource-constrained setting.

Methods: This qualitative study, conducted in a tertiary level diabetes clinic in India, included parents of children with T1D, selected from subgroups varying in disease duration, education, habitat, and socioeconomic status, who participated in one of the five Focused Group Discussions (FGDs) of 60-90 min duration.

Force Decay Behavior of Orthodontic Elastomeric Chains in Simulated Oral Conditions.

Background Elastomeric chains are widely used for incisor retraction and space closure. However, the force they exert diminishes over time, and this makes it difficult to determine the actual force transmitted to the dentition. The force decay may also be affected by exposure to saliva, foods, beverages, and prophylactic agents.

A Rare Case of Neuropathic Pain in Cutis Verticis Gyrata: A Review of Contemporary Literature.

Cutis verticis gyrata (CVG) is a rare benign neurocutaneous condition marked by thickened scalp folds resembling cerebral gyri and sulci. It has been classified into primary essential, primary non-essential, and secondary types. The primary essential type is idiopathic, and the primary non-essential type may be associated with neurological or ophthalmological complications.

A QbD-Navigated Approach to the Development and Evaluation of Etodolac-Phospholipid Complex Containing Polymeric Films for Improved Anti-Inflammatory Effect.

The current study focuses on development of phospholipid complex-loaded films of etodolac for enhanced transdermal permeation and anti-inflammatory effect. An etodolac-phospholipid complex was developed using the solvent evaporation method and was characterized by DSC, XRD, FTIR, and H-NMR studies. The formation of the complex led to conversion of a crystalline drug to an amorphous form.

A 'click' based fluorescent probe mimicking the IMPLICATION logic gate for Cu(II) and Pb(II) sensing: DFT and molecular docking studies.

'Click' derived 1,2,3-triazole appended scaffolds are intriguing candidates for selective metal ion recognition because of their stereospecificity and efficiency. The presented report uses the 'click' approach to introduce a glyoxal bis-(2-hydroxyanil)-based chemosensor probe (GT) the CuAAC pathway, which can selectively detect Cu(II) and Pb(II) ions, both of which are among the most hazardous and perturbing environmental pollutants. NMR spectroscopy, IR spectroscopy, and mass spectrometry (LCMS) were used to successfully characterize the synthesized probe.

An evidence based comprehensive review on thiacloprid, a pesticide residue, induced toxicity: Unveiling hazard to human health.

Thiacloprid, a hazardous neonicotinoid insecticide, prevalent in daily agricultural practices, raises concerns due to the harmful effects of its residues on food items, and on unintended organisms poses a significant threat to human health. Introduced in 1990, Thiacloprid have gained popularity for its perceived effectiveness and reduced risks to non-target animals. However, emerging research in recent years reports significant toxic effects of Thiacloprid on non-target species, spanning neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive issues.

Sodium orthovanadate protects against ulcerative colitis and associated liver damage in mice: insights into modulations of Nrf2/Keap1 and NF-κB pathways.

Ulcerative colitis (UC) is a prominent category of disease that is associated with bowel inflammation, it can occur at any period of life and is prevalently rising on a global scale. Dextran sulfate sodium (DSS) has been extensively used to develop colitis due to its ability to mimic human UC, providing consistent and reproducible inflammation, ulceration, and disruption of the epithelial barrier in the colon. Chronic inflammation in the gut can lead to alterations in the gut-liver axis, potentially impacting liver function over time, while direct evidence linking diversion colitis to liver damage is limited.

Effect of Integrated Nutrient Management on Soil Health, Soil Quality, and Production of Cowpea (Vigna unguiculata L.).

The integrated application of inorganic fertilizers, organic fertilizers, and biofertilizers helps sustain the nutrient pool and benefits the soil quality, thereby boosting plant health. The effect of different combinations of biofertilizers (consortium biofertilizer [CBF]-non-rhizobial PGPR), inorganic fertilizers, and organic fertilizers on soil health, growth, and yield of cowpea was evaluated by conducting a field experiment. The application of NFYM + CBF resulted in significantly higher populations of bacteria, fungi, PSB, and diazotroph, as well as soil dehydrogenase and alkaline phosphatase enzyme activities.

Mesoporous silica nanoparticles: a versatile carrier platform in lung cancer management.

Mesoporous silica nanoparticles (MSNPs) are inorganic nanoparticles that have been comprehensively investigated and are intended to deliver therapeutic agents. MSNPs have revolutionized the therapy for various conditions, especially cancer and infectious diseases. In this article, the viability of MSNPs' administration for lung cancer therapy has been reviewed.

Prevalence of bovine herpes virus-1 among reproductive disorders in cattle and buffaloes in Punjab region of India.

Bovine Herpes Virus (BHV-1) is a virus prevalent among cattle and buffaloes which accounts for considerable reproductive failures. This study was undertaken with the objective of studying the prevalence of BHV-1 in reproductive tract infections of cattle and buffaloes in Punjab region in India. A total of 70 reproductive tract samples (like vaginal mucous, cervical mucous, uterine discharges, uterine pus and aborted materials like placenta, caruncles, foetal stomach contents, amniotic fluid and placental fluid) were taken from cattle and buffaloes from various areas of Punjab which were suffering from different reproductive disorders.

From defense to dysfunction: Autophagy's dual role in disease pathophysiology.

Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic macromolecules as a guardian of cell metabolism, genomic integrity, and survival. In the complex play of biological warfare, autophagy emerges as a firm defender, bravely confronting various pathogenic, infectious, and cancerous adversaries.

Antibacterial Photodynamic Therapy of the Metallosurfactant-Fluorescein Conjugate under Visible Light Illumination.

Antibacterial photodynamic therapy (APDT) has received increased attention as a treatment for multidrug-resistant bacterial infections caused by antibiotic abuse. However, photosensitizers used in APDT have disadvantages such as water insolubility, self-aggregation, and photobleaching. To address these limitations, metal complexes have been explored.

Synthesis of triphyrin(2.1.1)-triphyrin(2.1.1) homo dimers and bis-Re(I) triphyrin dimer complex.

First examples of covalently linked triphyrin(2.1.1)-triphyrin(2.

Unraveling the cation dependent carrier cooling and transient mobility in lead-free A3Sb2I9 perovskites.

Lead halide perovskites (LHPs) have gained prominence for their exceptional photophysical properties, holding promise for applications in high-end optoelectronic devices. However, the presence of lead is one of the major obstacles to the commercialization of LHPs in the field of photovoltaics. To address this, researchers have explored environment friendly lead-free perovskite solar cells by investigating non-toxic perovskite materials.