"Minified" Goldmann applanating prism for tonometry in monkeys and humans.

The tip diameter of the standard Goldmann applanating prism was reduced from 7.0 mm to 4.0 or 4.

Filtering valve implant surgery for eyes wtih neovascular glaucoma.

We performed filtration surgery with a unidirectional, pressure-sensitive valve implant in 40 eyes with neovascular glaucoma. The device consisted of an open Supramid tube (outside diameter 0.58 mm, inside diameter 0.

Echothiophate-induced structural alterations in the anterior chamber angle of the cynomolgus monkey.

Four cynomolgus monkeys were treated topically twice daily in one eye with echothiophate iodide (PI) doses of 63, 75, or 250 micrograms per treatment for 7.7 weeks to 7 months. The opposite eyes of two monkeys received a control solution (diluent).

Aqueous humor dynamics following total iridectomy in the cynomolgus monkey.

Twenty-two cynomolgus monkeys underwent unilateral total iridectomy in vivo. Several weeks to several months postoperatively, intraocular pressure (IOP) was determined bilaterally by manometry under pentobarbital anesthesia (15 monkeys), by a minified Goldmann applanation tonometer under CI-744 anesthesia (16 monkeys), and by a minified Draeger applanation tonometer under light phencyclidine catalepsia (4 monkeys). Mean IOP in aniridic eyes was about 0.

Hyperopia and loss of accommodation following ciliary muscle disinsertion in the cynomolgus monkey: physiologic and scanning electron microscopic studies.

Twenty-three cynomolgus monkeys underwent 360-degree disinsertion and retrodisplacement of the ciliary muscle in one eye. Ten to 12 weeks after unilateral disinsertion, resting refraction in the "disinserted" eyes was more hyperopic than in the opposite eyes by 1.12 +/- 0.

Role of Indole-3-acetic Acid and Gibberellin in the Control of Internodal Elongation in Avena Stem Segments: Long Term Growth Kinetics.

Exogenous application of indoleacetic acid results in a significant suppression of the linear growth that is promoted by exogenous gibberellic acid in Avena stem segments in a fashion similar to that previously noted in Avena leaf base segments (van Overbeek and Dowding, 1961, Fourth International Conference Plant Growth Regulation). Treatment with the auxin transport inhibitors, methyl-2-chloro-9-hydroxyfluorene-(9)-carboxylate (CFM) or 2,3,5-triiodobenzoic acid (TIBA), alone promotes elongation growth of the stem segments over that of control growth. This effect is interpreted as being due to the interference in the transport of native indoleacetic acid by CFM and TIBA, thus removing the inhibitory effect of native indoleacetic acid on gibberellin-promoted growth in the internodal intercalary meristem.

Amaurosis and blood loss.

A 57-year-old alcoholic man sustained permanent bilateral blindness and optic atrophy as a complication of hemorrhage from peptic ulcer disease. Post-hemorrhagic visual loss occurs in middle-aged, debilitated persons a short time after repeated episodes of hemorrhage from any site.

Toxicity of combined therapy with carbonic anhydrase inhibitors and aspirin.

A 67-year-old woman and a 75-year-old woman taking carbonic anhydrase inhibitors for therapy of glaucoma and high doses of aspirin for therapy of arthritis developed severe acid-base imbalance and salicylate intoxication. Neither patient exhibited ill effects when taking high aspirin doses without carbonic anhydrase inhibitor. Carbonic anhydrose inhibitor-induced acidemia increases the risk of developing salicylate intoxication in patients receiving high aspirin doses.

Anticholinesterase-induced cholinergic subsensitivity in primate accommodative mechanism.

I treated cynomolgus monkeys with topical echothiophate iodide twice daily for several months. Accommodative responses to topical or intramuscular pilocarpine were determined after ciliary ganglion or cholinergic nerve blockade. During echothiophate treatment, there was little or no accommodative response to intramuscular pilocarpine doses which were near maximal in nonechothiophate-treated eyes.

Stabilizing Selection for Pupa Weight in TRIBOLIUM CASTANEUM.

Ninety-five generations of stabilizing selection for pupa weight in Tribolium castaneum resulted in a significant decrease in phenotypic variance, moderate reductions in additive genetic variance, but only slight changes in heritability for the trait. Sterility was significantly lower and the average number of live progeny per fertile mating was significantly higher in populations where stabilizing selection was practiced as compared with random selected populations. The results indicate that more genetic variability is being maintained than would be expected unless a fraction of the genes have a heterozygote advantage on the fitness scale.

Atropine inhibition of echothiophate cataractogenesis in monkeys.

One cynomolgus and three vervet monkeys were treated topicall twice daily in one eye with 63 microgram of echothiophate iodide and 750 microgram of atropine sulfate. The opposite eyes were treated with echothiophate alone. The eyes treated with echothiophate alone all developed posterior and/or anterior subcapsular cataracts within 26 to 66 days.

Formation and drainage of aqueous humor following total iris removal and ciliary muscle disinsertion in the cynomolgus monkey.

Aqueous humor formation (AHF), uveoscleral flow (U), gross outflow facility (Cg), true facility of outflow from the anterior chamber (Ct1), true facility of outflow from anterior chamber into the general circulation (Ct2), and the pressure sensitivity of AHF (pseudofacility; Cps) were determined in cynomologus monkey eyes which had undergone total iris removal or iris removal followed by ciliary muscle disinsertion. AHF was in the normal range in iridectomized-only eyes. AHF was present but reduced in "disinserted" eyes.

Light and electron microscopy of the anterior chamber angle structures following surgical disinsertion of the ciliary muscle in the cynomolgus monkey.

Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier.

Induction of subcapsular cataracts in cynomolgus monkeys by echothiophate.

Sixteen eyes of 13 cynomolgus monkeys were treated topically twice daily with echothiophate iodide. The dosages were increased gradually over several weeks to plateau levels ranging from 125 to 500 mug daily. The opposite eyes of the ten unilaterally treated monkeys received a control solution (DILUENT) identical save for the absence of echothiophate.

Cytochalasin B reversibly increases outflow facility in the eye of the cynomolgus monkey.

In cynomolgus monkeys, intracameral infusion of 0.2 to 5.0 mug of cytochalasin B caused an increase in outflow facility, as measured by two-level constant pressure perfusion.

Subsensitivity to pilocarpine of the aqueous outflow system in monkey eyes after topical anticholinesterase treatment.

Cynomolgus and vervet monkeys were treated unilaterally with topical echothiophate iodide twice daily for eight to 25 weeks. The effect of intracameral pilocarpine on outflow facility was determined in the ganglionic-blocked animal during and after echothiophate treatment. The echothiophate-treated eyes demonstrated marked subsensitivity to pilocarpine, and required several weeks to months to recover normal pilocarpine sensitivity.

Studies on acidification of media by Avena stem segments in the presence and absence of gibberellic Acid.

The rate of acidification of media by Avena stem segments was studied with a titrimeter. GA(3) increased this rate by an average of 17% if supplied to the segments 90 min prior to measurement. GA(3) inhibited the rate by 15% if supplied 10 min prior to measurement.