Plasma Proteome-Based Test for First-Line Treatment Selection in Metastatic Non-Small Cell Lung Cancer.

Purpose: Current guidelines for the management of metastatic non-small cell lung cancer (NSCLC) without driver mutations recommend checkpoint immunotherapy with PD-1/PD-L1 inhibitors, either alone or in combination with chemotherapy. This approach fails to account for individual patient variability and host immune factors and often results in less-than-ideal outcomes. To address the limitations of the current guidelines, we developed and subsequently blindly validated a machine learning algorithm using pretreatment plasma proteomic profiles for personalized treatment decisions.

Supported Natural Membranes on Microspheres for Protein-Protein Interaction Studies.

Multiple biological and pathological processes, such as signaling, cell-cell communication, and infection by various viruses, occur at the plasma membrane. The eukaryotic plasma membrane is made up of thousands of different lipids, membrane proteins, and glycolipids, and its composition is dynamic and constantly changing. Due to the central importance of membranes on the one hand and their complexity on the other, membrane model systems are instrumental for interrogating membrane-related biological processes.

Anaesthesiologists' views on the need for point-of-care information system in the operating room: a survey of the European Society of Anaesthesiologists.

Background And Objective: In this preliminary study we wanted to explore the attitudes of anaesthesiologists to a point-of-care information system in the operating room. The study was conducted as a preliminary step in the process of developing such a system by the European Society of Anaesthesiologists (ESA).

Methods: A questionnaire was distributed to all 2240 attendees of the ESA's annual meeting in Gothenburg, Sweden, which took place in April 2001.

Accuracy of transpulmonary thermodilution versus gravimetric measurement of extravascular lung water.

Objective: Pulmonary edema is a severe and often life-threatening condition. The diagnosis of pulmonary edema and its quantification have great clinical significance and yet can be difficult. A new technique based on thermodilution measurement using a single indicator has recently been developed (PiCCO, Pulsion Medical Systems, AG Germany).

Transpulmonary thermodilution cardiac output measurement using the axillary artery in critically ill patients.

Study Objective: To compare cardiac output (CO) as measured by the arterial thermodilution technique using only a central venous catheter and an arterial catheter inserted into the axillary artery, with conventional CO measurement with thermodilution using a pulmonary artery (PA) catheter (PAC).

Design: Prospective clinical study in which each patient served as his/her own control.

Setting: General ICU of a large tertiary-care teaching hospital.

Dental mirror for difficult nasotracheal intubation.

A patient with a previous surgical history of a cleft lip and palate repair and a pharyngeal flap pharyngoplasty was admitted for repair of mandibular prognathism. Following induction of anaesthesia, it was impossible to advance the nasotracheal tube into the oropharynx. Using a dental mirror and retrograde tracheal intubation equipment, under direct vision, the nasotracheal tube was finally advanced into the oropharynx.

Patient data management systems in anaesthesia: an emerging technology.

The purpose of this review is to define the expectations of an on-line automatic patient data management system (PDMS) into anaesthesia work-stations in and around the operating room suite. These expectations are based on review of available information in the medical literature, and trials of several systems that are available commercially, three of them in a more detailed fashion (i.e.

[Fentanyl vs alfentanil anesthesia for in vitro fertilization].

In a prospective double-blind study, 36 women undergoing ultrasonically guided oocyte retrieval for in vitro fertilization (IVF) were examined. Anesthesia in 19 was based on alfentanil, up to 0.025 mg/kg and in 17, fentanyl, 0.

Ventriculosubgaleal shunt: an effective CSF drainage in shunt disconnection.

A 4-year-old girl with a right ventriculoperitoneal shunt presented with a huge subcutaneous fluid collection in the scalp on the right side. There were no neurological symptoms or signs. On CT, a normal-sized ventricular system was seen.

Aspiration in caesarean section successfully treated with high continuous positive airway pressure (CPAP).

A case of aspiration pneumonitis during Caesarean section is described. The patient was treated with high-level continuous positive airway pressure (CPAP) resulting in marked improvement and discharge from the Intensive Care Unit 44 hours after the aspiration had occurred.

Observations on extradural morphine analgesia in various pain conditions.

We report the extradural administration of low-dose morphine in 10 ml of 10% dextrose (2-3 mg) to 98 adult patients with various types of acute and chronic pain. Extradural morphine injections were given either via a Tuohy needle (single or repeat injection) or via an extradural catheter. Pain relief was evaluated by subjective scoring and by the subsequent need for systemic analgesics.

Intermittent mandatory ventilation during anaesthesia using the Manley Servovent ventilator.

The lungs of 25 patients were ventilated with intermittent mandatory ventilation (IMV) during anaesthesia using the Manley Servovent Model MS. This ventilatory mode is especially suitable for prolonged operations in which there is no need for muscle relaxation. While incorporating the advantages of spontaneous and mechanical ventilation, it is superior to both in selected cases.

The variable effect of PEEP in acute respiratory failure associated with multiple trauma.

Both short and longterm effects of positive end-expiratory pressure (PEEP) on oxygenating capacity (OC) were investigated in three groups of patients with acute respiratory failure following multiple trauma (MT). Group A consisted of six patients with "uncomplicated" MT; Group B, eight patients with MT and generalized sepsis; Group C, nine patients with MT and lung contusion. OC was evaluated in terms of PaO2/FIO2 and P(A-a)DO2 on FIO 2 = 1.

Collapse of endotracheal tubes due to overinflation of high-compliance cuffs.

Overinflation of endotraceal-tube cuffs may seriously compromise the patient's airway, due to collapse of the wall of the endotracheal tube. Two case reports describe this complication, with x-ray demonstration of the hyperinflated cuffs.

The effect of PEEP on oxygenating capacity in acute respiratory failure with sepsis.

We report an evaluation of the effect of postive-end-expiratory-pressure (PEEP) on improving pulmonary oxygenating capacity in the adult respiratory distress syndrome (ARDS), when the latter is associated with generalized gram-negative sepsis. Fifty-seven cases treated in our RICU with PEEP ventilation (April 1972 to January 1975) were retrospectively reviewed. Oxygenating capacity improvement was evaluated in terms of the changes in PaO2/FIO2 and AaDO2 (FIO2 = 1.

Distortion of chest movement by increased airways resistance.

The movement of the chest during breathing has been recorded in normal and asthmatic subjects by means of electronic transducers which measured changes in anteroposterior and lateral diameters. Preliminary studies showed that exercise-induced bronchoconstriction caused distortion of the movement of the diameters in relation to each other and to volume change recorded at the mouth. Because of the thoracic gas compression which occurs during breathing, volume change at the mouth does not represent the change in chest volume and further studies were therefore undertaken in a whole-body plethysmograph.