Publications by authors named "Katy Staikin"
Recombinant ostreolysin induces brown fat-like phenotype in HIB-1B cells.
Mol Nutr Food Res
September 2017
Scope: Brown adipose tissue (BAT) is the main regulator of thermogenesis by increasing energy expenditure through the uncoupling of oxidative metabolism from ATP synthesis. There is a growing body of evidence for BAT being the key responsible organ in combating obesity and its related disorders. Herein we propose the fungal protein ostreolysin (Oly), which has been previously shown to bind to cholesterol-enriched raft-like membrane domains (lipid rafts) of mammalian cells, as a suitable candidate for interaction with brown preadipocytes.
View Article and Find Full Text PDFArticle Synopsis
- The corticotropin-releasing factor receptor type 1 (CRFR1) is crucial for the body's stress response, particularly in managing autonomic reactions.
- Research reveals that nearly half of the CRFR1 neurons in the arcuate nucleus of the hypothalamus also express agouti-related peptide (AgRP), with some originating from precursor neurons.
- In female mice lacking CRFR1 specifically in AgRP neurons, there is a notable failure in thermoregulation and glucose production during stress, indicating that CRFR1 is vital for proper sympathetic nervous system function under stress.