The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.

Background: We evaluated the effectiveness of nicorandil, which has both K(ATP) channel opener-like and nitrate-like properties, in liver ischemia-reperfusion (IR) injury using a porcine total hepatic vascular exclusion (THVE) model.

Methods: Mexican hairless pigs weighing 25-55 kg were used in this study. The animals were divided into three groups.