Protective Effect of EGb 761 Against Oxidative Phosphorylation of Brain Mitochondria After Anoxia/Reoxygenation In Vivo and In Vitro.

The aim of this study was to investigate the effects of in vivo and in vitro anoxia and reoxygenation on the oxidative phosphorylation of brain mitochondria and to study the protective effects of Ginkgo biloba extract (EGb 761). Cerebral ischemia and reperfusion induced slight decreases in respiration rates and in the efficiency of oxidative phosphorylation. Total protection of mitochondrial function was observed after chronic pretreatment of rat with EGb 761.