A quantitative description of the compatibility of technetium-selective chromatographic technetium-99m separation with low specific activity molybdenum-99.

Technetium-99m generators employing a technetium-selective stationary phase are a chromatographic instrument developed for use with Mo having low specific activity (LSA); particularly, Mo produced by electron accelerators. This paper presents a mathematical description of technetium-selective chromatographic (TSC) Tc separation and analyzes its compatibility with LSA Mo. We developed a theoretical formula for TSC Tc separation by discretizing its pertechnetate selectivity, and validated it using an electron linear accelerator and activated carbon-based TSC (AC-TSC) Tc generators.

A preliminary biodistribution study of [Tc]sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based Tc generator.

Introduction: Production of Mo/Tc using an electron linear accelerator (linac) and activated carbon (AC)-based Tc generator (linac-AC) is an alternative approach to the conventional fission production of Mo/Tc. As a preliminary investigation of the clinical applicability of a linac-AC-derived Tc radiopharmaceutical, the biodistribution of linac-AC-derived [Tc]sodium pertechnetate ([Tc]NaTcO) was measured and compared against fission-derived [Tc]NaTcO at one time point.

Methods: Mo was produced by irradiating nonenriched MoO targets with bremsstrahlung photons generated from 55.

Development of a radon trap device using a corona discharge.

Radon is one of the noble gases, which are chemically inert and do not make any reactants under normal conditions. In this experiment we demonstrated an enigmatic reaction between radon and fluorine when a corona discharge is used as a promoter. Distinctive changes in radon concentrations were caused by the discharge and a trap efficiency of >99.