Estimating age at death by Hausdorff distance analyses of the fourth lumbar vertebral bodies using 3D postmortem CT images.

The existing methods for determining adult age from human skeletons are mostly qualitative. However, a shift in quantifying age-related skeletal morphology on a quantitative scale is emerging. This study describes an intuitive variable extraction technique and quantifies skeletal morphology in continuous data to understand their aging pattern.

Dynamic imaging analysis reveals Auger electron-emitting radio-cisplatin induces DNA damage depending on the cell cycle.

Auger electrons can induce nanoscale physiochemical damage to DNA. The present study reports a sequential and systematic evaluation of the relationship between DNA damage such as double-strand breaks (DSBs) and the cell cycle for the Auger electron-emitting agent radiolabeled cisplatin with DNA binding ability. For dynamic imaging analysis, we used U2OS-derived cancer cells expressing two fluorescent fusion proteins: tumor-suppressor p53 binding protein 1 with a green fluorescent protein (53BP1-EGFP) and proliferating cell nuclear antigen with a red fluorescent protein (PCNA-DsRed).

Study on the Development of a New Device with Dual Cameras for Evaluating Expiratory Nasal Flow.

Background: Use of the Glatzel mirror for measuring expiratory nasal flow in preschool children has the disadvantage of vagueness, and the mirror may induce fear and inhibition of interest in those children. In response to these limitations, we developed a new device with dual cameras for measuring expiratory nasal flow in 2 to 6 year old children. The aim of this study is to compare the Glatzel mirror and the new device, in terms of accurate assessment of expiratory nasal flow, children's feelings, and correlation to each child's profile.

Near-Infrared Temperature Measurement Technique for Water Surrounding an Induction-heated Small Magnetic Sphere.

A technique to measure the temperature of water and non-turbid aqueous media surrounding an induction-heated small magnetic sphere is presented. This technique utilizes wavelengths of 1150 and 1412 nm, at which the absorption coefficient of water is dependent on temperature. Water or a non-turbid aqueous gel containing a 2.

Temperature imaging of water in a microchannel using thermal sensitivity of near-infrared absorption.

This paper presents a remote and preparation-free method of temperature imaging of aqueous solutions in microchannels of microfluidic chips. The principle of this method is based on the temperature dependency of the near-infrared (NIR) absorption band (ν(2) + ν(3) band) of water. Temperature images were constructed from absorbances in a narrow wavelength range including 1908 nm, the most sensitive to temperature in the band, measured by using an NIR camera and an optical narrow-bandpass filter.

Interactive segmentation of the cerebral lobes with fuzzy inference in 3T MR images.

Measurement of volume and surface area of the frontal, parietal, temporal and occipital lobes from magnetic resonance (MR) images shows promise as a method for use in diagnosis of dementia. This article presents a novel computer-aided system for automatically segmenting the cerebral lobes from 3T human brain MR images. Until now, the anatomical definition of cerebral lobes on the cerebral cortex is somewhat vague for use in automatic delineation of boundary lines, and there is no definition of cerebral lobes in the interior of the cerebrum.

Transcranial ultrasonography system for visualizing skull and brain surface aided by fuzzy expert system.

A conventional ultrasonography system can noninvasively provide human tissue and blood flow velocity information with real-time processing. In general, since the human skull prevents the disclosure of brain anatomy, we usually placed the sensor at the anterior and superior attachment site of the upper ear (the posterior temporal window) in adults. Due to this limitation, the conventional system cannot obtain transcranial information from arbitrary places in the skull.

Unique Solvent-Dependent Atropisomerism of a Novel Cytotoxic Naphthoxanthene Antibiotic FD-594.

The absolute stereochemistry of FD-594 1, a new cytotoxic antibiotic, was determined by X-ray diffraction, and its conformation was studied by CD and NMR spectroscopy. The aglycon part of 1 was found to have (3R,6S,7S) configuration. Particularly interesting was the solvent-dependent atropisomerism of 1 and related compounds.