Publications by authors named "Katsuya Fukuyama"
We report a new method to formylate phenol derivatives using formamidine acetate and acetic anhydride. This general-purpose transformation is a significant improvement over many other methods and does not require high temperatures or the addition of strong acid or base. Mono-, di-, and tri-formylated product can be obtained, depending on the substrate and conditions used.
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- Researchers have identified a new, gentle method for deuterating certain aromatic compounds that involves a keto-enamine tautomeric intermediate.
- The study utilized kinetics and computational analysis to understand the reaction mechanism, highlighting the importance of water molecules in reducing the activation barrier.
- The findings suggest that leveraging tautomeric forms of aromatic compounds can significantly increase their reactivity.
Engineering of well-organized tissue constructs is active in the field of material science for biomedical applications. Here, we propose a method for orienting collagen in transparent high-density collagen hydrogels using a simple rolling method. Structural organization and mechanical function were adjusted by regulating the thickness of the construct and the cross-linking reagent.
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