Cement Anchors With Screw Holes For Liner Cementation Into Cementless Acetabular Metal Shells.

This mechanical study was conducted with the shellcement interface in order to construct an acetabular metal shell, and to fix a polyethylene liner with bone cement. Six types of models were tested, with all cementations performed under similar conditions. The "lever out" test was conducted 3 times for each group in order to measure the dissociation strength.

Contact between the acetabulum and dome of a Kerboull-type plate influences the stress on the plate and screw.

We used a three-dimensional finite element method to investigate the conditions behind the Kerboull-type (KT) dome. The KT plate dome was divided into five areas, and 14 models were created to examine different conditions of dome contact with the acetabulum. The maximum stress on the KT plate and screws was estimated for each model.

Fixation strength at the interface between Kerboull-type plate and bone cement.

Purpose: To evaluate the fixation strength at the interface between the Kerboull-type plate and bone cement in 6 experimental conditions.

Methods: Experimental materials comprised a simulated acetabular block, a simulated Kerboulltype plate, a pressuriser cover, a pressuriser arm, and bone cement. The simulated Kerboull-type plate was placed on the simulated acetabular block, with the pressuriser cover.

Initial stability of cementless acetabular cups: press-fit and screw fixation interaction--an in vitro biomechanical study.

Background: Press-fit and screw fixation are important technical factors to achieve initial stability of a cementless acetabular cup for good clinical results of total hip arthroplasty. However, how these factors affect one another in initial cup fixation remains unclear. Therefore, this study aimed to evaluate the mutual influence between press-fit and screw fixation on initial cup stability.

Influence of the volume of bone defect, bone grafting methods, and hook fixation on stress on the Kerboull-type plate and screw in total hip arthroplasty: three-dimensional finite element analysis.

For total hip arthroplasty or revision surgery using acetabular reinforcement cross-plates, choosing between bulk and morselized bone grafts for filling acetabular defects is challenging. We used finite element model (FEM) analysis to clarify various stresses on the cross-plate based on bone defect size, bone graft type, and presence or absence of hook fixation to the bone. We constructed 12-pattern FEMs and calculated the maximum stress generated on the Kerboull-type (KT) plate and screw.

Comparison of levocetirizine pharmacokinetics after single doses of levocetirizine oral solution and cetirizine dry syrup in healthy Japanese male subjects.

Objective: Levocetirizine, the R-enantiomer of cetirizine, is classified as a second generation antihistamine used for the treatment of allergic disorders. This study aimed to compare exposure to levocetirizine when given as levocetirizine oral solution (OS) 5 mg to that when given as cetirizine dry syrup (DS) 10 mg, which contains equal proportions of levocetirizine and dextrocetirizine, in healthy Japanese male subjects.

Methods: The study was conducted in an open-label, single dose, randomized and two-way cross-over design.

Safety and pharmacokinetic evaluation of intravenous colistin methanesulfonate sodium in Japanese healthy male subjects.

Objectives: The study aimed at evaluating the pharmacokinetics of colistin methanesulfonate sodium (CMS-Na) and describing observed safety findings in Japanese healthy male subjects.

Methods: A total of 22 Japanese healthy males were enrolled in this randomized double-blind, placebo controlled study. Dosing regimens of a single dose and twice-daily repeat doses of CMS-Na (2.

Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model.

Bone repair involves a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone matrix at the fracture site. It has been reported that the optimal time point for single-dose zoledronic acid (ZA) administration systemically increased the strength of bone morphogenetic protein (BMP)-7-mediated callus. However, its repair mechanism during bone fracture healing remains unknown.

Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.

This study was performed to investigate the pharmacokinetics of valaciclovir (VACV), aciclovir (ACV) and 9-(carboxymethoxy)methylguanine (CMMG) in Japanese chronic hemodialysis patients following a single oral administration of 1000 mg VACV and the influence of genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) on their pharmacokinetics. A total of eighteen individuals genotyped as ALDH2*1/*1, ALDH2*1/*2 or ALDH2*2/*2 were enrolled in this study. Blood samples were obtained pre-dose and up to 48 hour post-dose.

Analysis of wear and oxidation on retrieved bipolar polyethylene liner.

Background: For bipolar prostheses, most of the previous studies attributed the occurrence of osteolysis to wear debris generated from the bearing surface. We looked closely into the wear debris and reported on our findings with respect to the oxidation index and the rate of wear in ultra-high molecular weight polyethylene (UHMWPE) inserts retrieved from bipolar prostheses after various spans of time in vivo.

Method: The inserts were retrieved from the heads of three types of bipolar prosthesis (UH1, UPF1, UPF2).