Publications by authors named "Katsuro Enomoto"
Background: Mutations in GNAS drive pancreatic tumorigenesis and frequently occur in intraductal papillary mucinous neoplasm (IPMN); however, their value as a therapeutic target is yet to be determined. This study aimed at evaluating the involvement of mutant GNAS in tumor aggressiveness in established pancreatic cancer.
Methods: CRISPR/Cas9-mediated GNAS R201H silencing was performed using human primary IPMN-associated pancreatic cancer cells.
Background/objectives: Decrease in skeletal muscle mass and function is associated with a poor prognosis following surgical resection of pancreatic ductal adenocarcinomas (PDAs). This study evaluated whether skeletal muscle mass decrease affects PDA outcomes.
Methods: Data of 112 patients with advanced and unresectable PDA who underwent chemotherapy in a single institution were retrospectively analyzed.
Article Synopsis
- Cell-free DNA (cfDNA) from tumors can help in diagnosing pancreatic ductal adenocarcinoma (PDA) and monitoring intraductal papillary mucinous neoplasm (IPMN) using advanced digital PCR methods.
- A study involving plasma samples from multiple institutions analyzed mutations in KRAS and GNAS among patients with PDA, those under IPMN surveillance, and healthy controls, revealing that cfDNA measurements can effectively differentiate between these groups.
- The results show that digital PCR outperforms traditional markers in detecting tumor-related mutations and predicting post-surgery recurrence, making cfDNA quantification a valuable tool for cancer assessment and management.
Background & Aims: Intraductal papillary mucinous neoplasms (IPMNs) are regarded as precursors of pancreatic ductal adenocarcinomas (PDAs), but little is known about the mechanism of progression. This makes it challenging to assess cancer risk in patients with IPMNs. We investigated associations of IPMNs with concurrent PDAs by genetic and histologic analyses.
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