Publications by authors named "Katsumichi Takeda"
Article Synopsis
- Neuropathic pain from sciatic nerve injury affects not only peripheral functions but also alters brain regions, potentially impacting behavior and neurochemistry.
- The study explores how peripheral neuropathic pain leads to mechanical allodynia and changes in neuropeptide levels and microglial activity in rats, especially following chronic constriction injury.
- Treatment with memantine shows promise in suppressing pain-related changes by reducing neuropeptide levels and microglial activation, indicating that neuropeptides and microglial cells play vital roles in the pain signaling processes in the brain.
A new sensitive and automated chemiluminescent assay was developed for the quantitative determination of hepatitis C virus (HCV) core antigen (Ag) in human sera or plasma: the Abbott ARCHITECT HCV Ag test. The assay sensitivity was determined by testing 10 commercial HCV seroconversion panels. Without exception, a positive result for HCV core Ag was observed before anti-HCV detection, resulting in an average reduction in the period between exposure and detection of 35.
View Article and Find Full Text PDFBackground/aims: Although serum assays for pro-gastrin-releasing peptide (ProGRP) assays have been commercially available in Japan for several years, the stability of ProGRP in serum and plasma has not been well documented. We investigated the stability of ProGRP in serum and plasma with fresh and stored (frozen) specimens, as well as the cause of the observed instability in serum.
Methods/results: ProGRP concentrations in fresh serum were decreased by 6-28% after room temperature storage for 2 h and by 8-32% after 2-8 degrees C storage for 24 h.