Publications by authors named "Katsumasa Kanda"
Proc Natl Acad Sci U S A
April 2010
Article Synopsis
- - The study investigates the O(2) reduction site of cytochrome c oxidase (CcO) using x-ray structural analyses of various derivatives to understand how oxygen is fully reduced, focusing on the roles of iron and copper ions.
- - When O(2) binds to the iron site, it becomes negatively polarized, triggering structural changes that facilitate the sequential transfer of electrons, which helps minimize the formation of harmful reactive oxygen species.
- - The bovine CcO's proton-pumping mechanism involves a hydrogen-bond network and a water channel, where certain ligand bindings like CO or NO can restrict water access, efficiently blocking proton back-leak and enhancing proton-pumping capability.
