Prevention of cleft lip and/or palate in A/J mice by licorice solution.

Cleft lip and/or palate anomalies (CL ± P) are the most frequent birth defects affecting the orofacial region in humans. Although their etiology remains unclear, the involvement of environmental and genetic risk factors is known. This observational study aimed to investigate how the use of  crude drugs with estrogen activity influenced an animal model's ability to prevent CL ± P.

Does skeletal surgery for asymmetric mandibular prognathism influence the soft tissue contour and thickness?

Purpose: The purpose of the present study was to investigate whether asymmetric mandibular prognathism accompanies a fundamental difference in soft tissue thickness and whether asymmetric mandibular setback surgery would influence the contour and thickness of the soft tissue of the chin.

Materials And Methods: The present retrospective study included skeletal class III patients with significant mandibular chin deviation greater than 6 mm at the pogonion, who had undergone cone-beam computed tomography before and 6 months after surgery during a 2-year period. The predictor variables were timing (pre- and postoperatively) and side (asymmetric vs contralateral).

Evaluation of pterygomaxillary anatomy using computed tomography: are there any structural variations in cleft patients?

Purpose: Structural characteristics of the pterygomaxillary region in patients with cleft lip and palate (CLP) have not been fully investigated. This study aimed to evaluate the regional anatomy of the pterygomaxillary junction of patients with CLP using computed tomography.

Materials And Methods: The pterygomaxillary structures of patients with unilateral or bilateral CLP were compared with those of a control group using axial computed tomography.

Development of a simulation system in mandibular orthognathic surgery based on integrated three-dimensional data.

Purpose: Surgical simulation should reflect the 3D movement of dentition and the resultant movement of the osteotomized segments, which can influence surgical outcome. The present study was aimed at developing a new simulation system that enables virtual osteotomy of a given surgical situation and evaluation of the bony interference between the osteotomized segments of the mandible.

Subjects And Methods: The data of 3D computer tomography (CT) for maxillomandibular dental casts were integrated into the standard coordinates of a 3D cephalogram.

Diagnosis and treatment of an infant case with temporomandibular joint osteoarthritis caused by tumor.

Introduction: We reported an infant with temporomandibular joint (TMJ) osteoarthritis who required long-term tracheostomy.

Case Findings: At 1 year of age, he received urgent tracheostomy because of apnea due to pneumonia. The tracheal cannula could not be removed thereafter due to trismus.

Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.

Cleft lip with or without cleft palate (CL/P) is a complex trait with evidence that the clinical spectrum includes both microform and subepithelial lip defects. We identified missense and nonsense mutations in the BMP4 gene in 1 of 30 cases of microform clefts, 2 of 87 cases with subepithelial defects in the orbicularis oris muscle (OOM), 5 of 968 cases of overt CL/P, and 0 of 529 controls. These results provide confirmation that microforms and subepithelial OOM defects are part of the spectrum of CL/P and should be considered during clinical evaluation of families with clefts.

Maxillary distraction osteogenesis in cleft lip and palate patients with skeletal anchorage.

Objective: Maxillary distraction osteogenesis with the rigid external distraction (RED) system has been used to treat cleft lip and palate (CLP) patients with severe maxillary hypoplasia. We introduce maxillary distraction osteogenesis for CLP patients with skeletal anchorage adapted on a stereolithographic model.

Patients: Six maxillary deficiency CLP patients treated according to our CLP treatment protocol had undergone maxillary distraction osteogenesis.

Three-dimensional facial morphology, following primary cleft lip repair using the triangular flap with or without rotation advancement.

Introduction: There are numerous methods of repairing a cleft lip. In our institution, two methods have been used for primary lip repair, the triangular flap method, and the rotation-advancement plus small triangular flap method. The purpose of this study was to compare postsurgical anthropometric results following these two surgical methods.

Three-dimensional analysis of facial morphology in normal Japanese children as control data for cleft surgery.

Objective: This study presents an analysis of three-dimensional facial forms of normal Japanese children.

Design And Setting: Cross-sectional data (n = 247) were available from the Ikeda Public Health Center.

Patients And Participants: Three groups of children (ninety-seven 4-month-old infants, fifty-four 1.

Surgical results of primary lip repair using the triangular flap method for the treatment of complete unilateral cleft lip and palate: a three-dimensional study in infants to four-year-old children.

Objective: To evaluate morphological problems for children with complete unilateral cleft lip and palate (UCLP).

Design And Setting: A cross-sectional study was performed on 46 patients with complete UCLP at Osaka University Dental Hospital.

Patients And Participants: The method was applied to three groups of children with UCLP (8 4-month-old infants, 18 1.

Reproducibility of maxillary positioning in Le Fort I osteotomy: a 3-dimensional evaluation.

Purpose: In the present study, we evaluated the difference between the model surgery movement and the actual surgical movement in the horizontal (X), vertical (Y), and transverse (Z) directions using the same reference coordinates.

Patients And Methods: Twelve patients (6 male and 6 female, mean age of 24.3 years) who underwent Le Fort I osteotomy and sagittal split ramus osteotomy were included in the study.