Publications by authors named "Katsuhiro Iinuma"

Membrane-based rapid test reagents including immunochromatography are widely used in clinical practice. Recently, high-sensitive reagents based on the immunochromatography method, such as silver amplification method and time resolved fluorescence method for influenza testing, has been developed and early confirmation of infection can be achieved. Furthermore, genetic testing, automated all the steps from extraction till detection, is getting popular.

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Background: Acne vulgaris is a common dermatological disease, and its pathogenesis is multifactorial.

Objective: We examined whether the ascorbic acid derivative zinc ascorbate has superoxide dismutase (SOD)-like activity. SOD is an enzyme that controls reactive oxygen species production.

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Purpose: The in vitro antimicrobial activity of ascorbic acid derivatives against Propionibacterium acnes was tested either alone or in combination with a variety of antimicrobial agents, and their fractional inhibitory concentration index was determined using checkerboard tests. The antimicrobial effectiveness of zinc ascorbate in the treatment of acne vulgaris, either alone or in combination with antibiotics such as clindamycin that are commonly used in Japan for the treatment of acne vulgaris, was therefore examined.

Materials And Methods: The antimicrobial susceptibility of 41 strains of clindamycin-sensitive and/or clindamycin-resistant P.

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Article Synopsis
  • Lipopolysaccharide (LPS) from Gram-negative bacteria triggers inflammatory responses in skin, specifically affecting the epidermis and sebaceous glands.
  • In a study, administering E. coli-derived LPS to hamsters led to increased epidermal thickness and higher levels of cyclooxygenase 2 (COX-2) and prostaglandin F(2α) (PGF(2α)) in sebaceous glands.
  • The findings suggest that LPS enhances inflammation in the skin by increasing COX-2, PGF(2α), and proMMP-2 production, potentially contributing to skin disorders like acne and folliculitis.
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Propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, but it remains unclear whether P. acnes directly influences lipogenesis in sebaceous glands. In this study, we showed that a culture medium of P.

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