Three-dimensional finite element analysis of fixed complete-arch prostheses supported by 4 immediate-loaded implants in the completely edentulous maxilla using clinical computerized tomography data.

Mechanical simulation by loading an occlusal force (load), assumed to be that loaded under clinical conditions, was performed in a computerized tomography (CT) data-based immediate-loaded implant placement simulation. Stresses on and displacements of the implants and surrounding bone tissue were analyzed mechanically using 3-dimensional finite element analysis (FEA). The purpose of this study was to investigate the possibility of practical preoperative design and its evaluation and to assess the effects of connected fixation.

Preoperative assessment of treatment planning on minimization of micro-movement during healing period of immediate-loaded implants using X-ray CT data-based simulation.

Abstract The purpose of this study was to investigate the possibility of practical preoperative design and its evaluation and to assess the effects of connected fixation on minimization of micro movement during healing period of immediately loaded implants.Mechanical simulation by loading an occlusal force (load), assumed to be that loaded under clinical conditions, was performed in a computed tomography (CT) data-based immediate-loaded implant placement simulation. Stresses on and displacements of the implants and surrounding bone tissue were analyzed mechanically using three-dimensional finite element analysis.

Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells.

Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c and the activation of caspase proteases in the human B cell line NALM-6. Induction of apoptosis by trimidox (300 microM) was detected in NALM-6, HL-60 (premyelocytic leukaemia cells), MOLT-4 (an acute lymphoblastic leukaemia cells), Jurkat (a T-cell leukaemia cells), U937 (expressing many monocyte-like characteristics), and K562 (erythroleukaemia).

Octylcaffeate induced apoptosis in human leukemia U937 cells.

We found that octylcaffeate, a semisynthetic caffeic acid derivative, strongly inhibited the growth of human histiolytic lymphoma U937 cells in a dose- and time-dependent manner via apoptosis. Octylcaffeate induced the fragmentation of DNA into multiples of 180 bp (an apoptotic DNA ladder) and condensation of chromatin, and increased the percentage of hypodiploid cells detected with a flow cytometer. DNA fragmentation induced by octylcaffeate was inhibited by pretreatment with Z-DEVD-FMK and Z-Asp-CH(2)D-CB, an inhibitor of caspase, clearly showing that the mode of cell death is apoptotic.

Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.

We have investigated the effect of naringenin (NGEN) on tumor growth in various human cancer cell lines and sarcoma S-180-implanted mice. NGEN showed cytotoxicity in cell lines derived from cancer of the breast (MCF-7, MDA-MB-231), stomach (KATOIII, MKN-7), liver (HepG2, Hep3B, Huh7), cervix (Hela, Hela-TG), pancreas (PK-1), and colon (Caco-2) as well as leukemia (HL-60, NALM-6, Jurkat, U937). NGEN-induced cytotoxicity was low in Caco-2 and high in leukemia cells compared to other cell lines.