Determination of action spectrum for sparfloxacin-photosensitized single-strand breaks in plasmid pBR322 DNA.

Background: Various drugs have been reported to induce photosensitivity as a side effect. Sparfloxacin (SPFX) is well known to trigger dermatological phototoxicity upon solar radiation exposure.

Purpose: To prevent SPFX-induced phototoxicity, we determined the wavelength range responsible for SPFX phototoxicity.