Publications by authors named "Katsuhide Kayano"
Article Synopsis
- * Researchers collected blood samples and analyzed the changes in granulocyte and monocyte subtypes before and after GMA using advanced mass cytometry techniques.
- * Findings indicate that specific activated neutrophil and monocyte subsets, which promote inflammation and T cell activation, are targeted by GMA, potentially explaining its therapeutic benefits in severe COVID-19 and similar inflammatory conditions.
Neutrophil phenotypes implicated in the pathophysiology of post-traumatic sepsis.
Front Med (Lausanne)
December 2022
Background: The disruption of immune homeostasis after trauma is a major cause of post-traumatic organ dysfunction and/or sepsis. Recently, a variety of neutrophil phenotypes with distinct functions have been identified and suggested as involved in various clinical conditions. The association between neutrophil phenotypes and post-traumatic immunodeficiency has also been reported, yet the specific neutrophil phenotypes and their functional significance in post-traumatic sepsis have not been fully clarified.
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- The study aimed to understand immune changes in critically ill COVID-19 patients during their recovery over a year.
- Researchers analyzed immune responses in patients at various recovery stages using advanced single-cell techniques, comparing their immune profiles with those of healthy individuals.
- Results showed increased levels of certain immune cells like T lymphocytes and natural killer cells in recovering patients, indicating a sustained immune response over the recovery period.
Background: Various animal models of sepsis have been developed to optimize sepsis treatment. However, therapeutic agents that were successful in animal models were rarely effective in human clinical trials. The cecal ligation and puncture (CLP) model is currently the gold standard for sepsis studies.
View Article and Find Full Text PDFWe evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients.
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