[The influence of dehydroepiandrosterone (DHEA) on the behavior in old non-human primates].

At present time there is a lack of satisfactory understanding of how DHEA affects cognition and nervous system function. Aim of the present study to evaluate effects of long-term DH EA administration of physiological doses on the Higher Brain Activity (HBA) in rhesus macaques (RM) at the limits of their biological age. The study included 9 male RM aged 24-30 years.

[Obesity and development of metabolic syndrome in androgen-deficient young men].

Results of this study and literature data provide convincing evidence of the association between metabolic syndrome and male hypogonadism. International studies demonstrated beneficial effect of exogenous testosterone on body mass, lipid metabolism, insulin secretion and sensitivity as well as reduction of AP and fat tissue volume, i.e.

[Dehydroepiandrosterone and the cerebral functions].

Of all steroidal hormones, dehydroepiandrosterone (DHEA) and its sulphate form, DHEAS, are synthesized by the adrenal glands in the biggest quantities. In this review the authors consider the ways of the synthesis of the neurosteroids, possible mechanisms of the regulation of these processes, and their dynamics under stressful conditions. The paper presents analysis of experimental and clinical data on the role of DHEAS in the manifestation of different cerebral functions.

[Dehydroepiandrosterone and brain functioning].

The adrenal glands synthesize dehydroepiandrosterone (DHEA) and its sulphate form (DHEAS) more intensively than they do other steroid hormones. Researchers are interested in these hormones for several reasons. Firstly, for some years they have been trying to find the reason for DHEA and DHEAS to be synthesized and present in the organism in such high concentrations.

[Neurosteroids and their biological significance].

The paper summarizes the current knowledge concerning various aspects of neurosteroid metabolism and mode of action. These steroid compounds including dehydroepiandrosterone, pregnenolone, and their sulfates, as well as progesterone and its tetrahydro metabolites, are synthesized de novo in glial cells of different brain structures both in humans and in animals. Biological effects of neurosteroids and their fundamental and clinical aspects are reviewed.

Results of hospital bypass angiography in patients with coronary artery disease undergoing arterial and vein myocardial revascularization.

This paper analyzes the results of 94 coronary artery bypass grafts accomplished at the Department of Surgical Treatment of Concomitant Lesions of Coronary and Peripheral Arteries, A.N. Bakulev SCCVS, RAMS, in patients with coronary artery disease (CAD) provided control hospital bypass angiography over the period 1998 to 2002.

[Effect of corticoliberin and naloxone on the functional activity of the hypophyseal-gonadal system in monkeys].

Experiments were staged on male Papio hamadryas for a study of CRF and naloxone action on the time course of LH and testosterone in peripheral blood. LH was determined by a biological micromethod in vitro; ACTH, cortisol and testosterone were determined by radioimmunoassays. Exogenous CRF was shown to increase inhibitory action of acute "procedure" stress (frequent fixation of monkeys and venipuncture for taking blood samples) of the secretion of LH but not testosterone.

[The role of ACTH in regulating dehydroepiandrosterone secretion in primates].

The effect of repeated administration of a prolonged ACTH agent on the secretion of glucocorticoids, dehydroepiandrosterone (DEA) and delta 4- and delta 5-precursors was studied in experiments on male hamadryas baboons. The administration of Sinacten-depot at a dose of 1 mg for 5 days caused a noticeable decrease in the basal levels of cortisol, 11-deoxycortisol, pregnenolone, 17-oxypregnenolone, and DEA. Response of the adrenal glands to additional ACTH stimulation against a background of lowered basal indicators was completely preserved and increased 2-3-fold for pregnenolone, 17-oxypregnenolone and DEA.

[Effect of immobilization stress on the gonadotropic function of the hypophysis in male hamadryas baboons (Papio hamadryas)].

The plasma levels of luteinizing hormone (LH) and testosterone were studied in intact and castrated male baboons exposed to 2- and 10-hour periods of immobilization. Presented data have shown that immobilization stress induced a marked decrease in LH concentration both in intact and castrated monkeys. Changes in LH concentration positively correlated with plasma levels of testosterone only during the experimental procedures.

[The use of a radioimmunologic method of analysis of 11-deoxycortisol for the evaluation of the function of the pituitary-adrenal cortex system during the metopirone test].

A radioimmunoassay of II-deoxycortisol in human and animal blood plasma was developed. The antiserum used in the method was prepared against a conjugate of II-deoxycortisol-3(0-carboxymethyloxime) and bovine serum albumin. Specificity of the antiserum was determined in cross reactions using 32 steroids.

[Psychopathological and hormonal manifestations of alcoholic intoxication and emotional stress in monkeys].

Ethological approach to studying mature P. hamadryas and M. mulatta males has revealed a wide spectrum of changes in individual and zoosocial behaviour in response to the administration of different alcohol doses and stress stimuli.

[Effect of luliberin on the secretion of luteinizing hormone as a function of the phase of menstrual cycle in intact and castrated female Papio hamadryas].

A comparative study of the LH time course in response to the administration of a standard dose of LH/RF was conducted in intact and castrated female papio hamadryas to find out the relationship between hypophyseal sensitivity to LH/RF action and the level of sex steroid hormones in the peripheral blood. A bioradioimmunoassay adapted for the monkey plasma was employed to measure the level of biologically active LH in the peripheral blood plasma. A stimulating effect of LH/RF on the hypophyseal LH secretion both in intact animals in different phases of the menstrual cycle and in gonadectomized females was established.

[Effect of prolonged hypokinesia on the gonadal and adrenal function of female hamadryas baboons].

A radioimmunoassay was used to study the effect of 26-day clinostatic hypokinesia on the level of sex hormones and cortisol in the peripheral blood plasma of 10 female papio hamadryas immobilized in different phases of the menstrual cycle. A significant decrease in the level of estradiol in the follicular phase and progesterone in the luteal phase was shown whereas the levels of cortisol and testosterone did not practically vary. Dependence of the adrenal gland reactivity to an acute immobilization stress on a cycle phase with minimal values in the luteal period was shown.

[Effect of adrenocorticotropic hormone on the secretory activity of the gonads and adrenals of male hamadryas baboons].

The time course of the secretion of steroid hormones to the adrenal and seminal veins following administration of synthetic ACTH was studied in experiments on mature male hamadryas baboons. Testosterone, 5 alpha-dihydrotestosterone, androstendion, 17-oxyprogesterone and 17-oxypregnenolone levels in the venous blood were determined by means of radioimmunoassays with preliminary chromatographic isolation of steroids on cellite. The rate of hormone secretion by the adrenal and seminal glands was calculated by the gradient of the hormone concentration in the peripheral blood and in the blood outflowing from the steroid secreting glands.

[Effect of ACTH on the corticosteroid and progesterone levels in female hamadryas baboons in relation to the menstrual cycle phase].

The effect of exogenous ACTH on the endogenous function of the steroid-producing glands has been investigated in hamadryas baboon females depending on the level of sex hormones in the body. The content of corticosteroids and progesterone in peripheral blood plasma was measured by radioimmunoassay. It has been established that the time course of changes in the adrenal gland response to administration of a standard ACTH dose was of the same type in the different menstrual cycle phases.

[Effect of gonadectomy and luliberin on the gonadotropic function of the hypophysis in Papio hamadryas].

A comparative study was made of the effect of LH-RH on the hypophyseal reactivity in intact and castrated male papio hamadryas. Hypophysis gonadotropic function was evaluated by the content of the biologically active luteinizing hormone in the peripheral blood plasma which was determined by an in-vitro biological method. Bilateral gonadectomy caused an increase in the luteinizing hormone concentration by an average of 600% in this species of apes.