Publications by authors named "Katsiaryna V Gris"

Article Synopsis
  • The study used automated software to analyze 24-hour recordings of mice over 11 days, allowing researchers to identify and cluster 33 different mouse activities into novel behavioral patterns.
  • The activities were grouped into 5 clusters and 6 factors based on statistical methods, comparing behaviors of mice in social isolation with those that experienced intermittent socialization.
  • This research establishes a baseline for normal behaviors in C57Bl/6J mice, which could be invaluable for future studies in disease models, neuroinflammation, or drug testing, and it also outlines the acclimatization needed for accurate 24-hour behavior recordings.
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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) associated with inappropriate activation of lymphocytes, hyperinflammatory responses, demyelination, and neuronal damage. In the past decade, a number of biological immunomodulators have been developed that suppress the peripheral immune responses and slow down the progression of the disease. However, once the inflammation of the CNS has commenced, it can cause serious permanent neuronal damage.

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Quantifying behavior is a challenge for scientists studying neuroscience, ethology, psychology, pathology, etc. Until now, behavior was mostly considered as qualitative descriptions of postures or labor intensive counting of bouts of individual movements. Many prominent behavioral scientists conducted studies describing postures of mice and rats, depicting step by step eating, grooming, courting, and other behaviors.

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