Publications by authors named "Katsiaryna Maskalenka"
Gene duplication events can drive evolution by providing genetic material for new gene functions, and they create opportunities for diverse developmental strategies to emerge between species. To study the contribution of duplicated genes to human early development, we examined the evolution and function of NANOGP1, a tandem duplicate of the transcription factor NANOG. We found that NANOGP1 and NANOG have overlapping but distinct expression profiles, with high NANOGP1 expression restricted to early epiblast cells and naïve-state pluripotent stem cells.
View Article and Find Full Text PDFInduced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low). Sox2-low nPSCs do not show impaired neuroectoderm specification and differentiate efficiently into all embryonic germ lineages.
View Article and Find Full Text PDFArticle Synopsis
- Researchers explored how cells transition into a naive pluripotent state, discovering that this process can happen through different pathways.
- One pathway involves a mesodermal state, while another resembles the early inner cell mass, leading to a greater ability to develop into various cell types.
- Both pathways eventually converge into the same naive pluripotent state, emphasizing the flexibility of these identity transitions and highlighting the essential role of the transcription factor Oct4 in regulating this process.