Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond.

Background: Genetic and epigenetic changes, oxidative stress and inflammation influence the rate of aging, which diseases, lifestyle and environmental factors can further accelerate. In accelerated aging (AA), the biological age exceeds the chronological age.

Objective: The objective of this study is to reappraise the AA concept critically, considering its weaknesses and limitations.