[Comparative anti-angina effectiveness of metoprolol and propranolol].

A study of comparative antianginal efficiency of metoprolol (betaloc) and propranolol (anaprilin) in 30 patients with angina of effort, receiving single doses and courses of the treatment, demonstrated similar efficiency of the two drugs in 63.3% of the patients. In 30%, antianginal effect of metoprolol was superior to that of propranolol.

[Cerebral hemodynamics and bioelectric activity of the brain in ischemic heart disease].

Rheoencephalographic and electroencephalographic studies were conducted in 102 male coronary patients. Mathematical amplitude-frequency analysis demonstrated symptoms of cerebral blood flow decrease and hypoxia, which were dependent on the functional class of angina for their severity.

Epidemiology and possibility of prevention of ischaemic heart disease risk factors among students in various USSR regions. Programme and first results of All-Union Cooperative Study.

Screening examination of 12,191 students in their first year of study at medical faculties and technical institutes in Moscow, Kharkov, Alma-Ata and Tashkent showed the following prevalence of major risk factors of ischaemic heart disease among males and females: arterial hypertension: 4.6-17%; 1.2-6.

[Effect of corinfar on the course of angina pectoris and indices of carbohydrate metabolism in relation to the type of glucose tolerance].

Nifedipine influence on a clinical course of angina pectoris, some indices of hemodynamics, glucose and insulin was studied in 39 male patients suffering from coronary heart disease (CHD) with different glucose tolerance. In CHD patients with normal glucose tolerance (NGT) nifedipine therapy did not cause any considerable changes in the blood levels of glucose and insulin whereas in patients with lowered glucose tolerance (LGT) a hypoglycemic effect of the drug and an increase in the level of insulin were noted during therapy. An increase in physical exercise tolerance, a decrease in the frequency of anginal attacks, and a decrease in the number of nitroglycerin tablets administered by CHD patients with LGT per week were significant.

[Various aspects of the effects of beta adrenergic receptor blockaders, stimulants and calcium antagonists on the cardiovascular system].

Experiments with isolated animal hearts showed that intracoronarily injected propranolol (beta-adrenoblocker) and nonachlasine (beta-adrenostimulator) lead to coronary dilatation changing into coronary constriction. Unlike propranolol, nonachlasine reduced the venous bed capacity. The use of nonachlasine resulted in primary reduction and consequent increase of myocardial contractility, propranolol leading to negative inotropic effect.

[Mechanisms of the inotropic action of nonachlazine].

It has been demonstrated clinically and experimentally that administration of nonachlazine enhances myocardial contractility because of the stimulation of beta-adrenostructures and that the initial status of the latter ones determines in many respects the drug action intensity.

[Changes in the physical load tolerance of stenocardia patients taking obzidan, korinfar and izoptin separately and together].

Changes in exercise tolerance under the impact of obsidan, corinfar, isoptin and their combinations were studied in 12 angina patients with the help of bicycle ergometry. The most marked increase in exercise tolerance following the use of a single drug was observed with obsidan (85.1 +/- 35.

[Effect of obzidan on the indices of gas exchange and the sympathetic-adrenal system in ischemic heart disease patients with different types of circulation].

The relationship between the effect of propranolol treatment on oxygen consumption during exercise and the activity of the sympathoadrenal system (SAS) and the initial hemodynamic circulatory type was established in patients with coronary heart disease (CHD). In patients with the hyper- and eukinetic circulatory types, propranolol caused an increase in the maximal oxygen consumption (MOC), pointing to the improvement of the functional possibilities of the cardiovascular system during exercise, with this improvement being more marked in patients with the hyperkinetic type. This effect of propranolol in the latter group patients was coupled with a reduction in the transmitter activity of the SAS.