Publications by authors named "Katrine Schou Sandgaard"
Article Synopsis
- Recent studies indicate that young people with perinatally acquired HIV (PHIV) experience a decrease in their CD4 count during adolescence, particularly after age 10.
- The study analyzed 1,258 individuals with PHIV in the UK, finding that those who began antiretroviral therapy (ART) before age 10 and had a higher nadir CD4 z score maintained better CD4 counts than those with lower scores.
- The findings suggest that starting ART earlier and managing it effectively to keep higher CD4 levels in childhood is crucial for better immune health in later years.
Article Synopsis
- - Current guidelines recommend all children with HIV-1 infection receive antiretroviral therapy (ART) to enhance health outcomes, yet prior treatments were not timely for everyone, leaving gaps in immune response understanding.
- - A study analyzed 11 adolescents with HIV-1 on ART, comparing those with well-controlled viral loads and CD4 counts to those with poor control, focusing on T cell receptor (TCR) diversity and output from the thymus.
- - Findings show that adolescents with effective HIV-1 suppression had higher TCR diversity and CD4 counts, suggesting robust immune responses, while those with poor suppression had diminished thymic output and TCR diversity, highlighting the importance of prompt and effective ART.
It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4 T cell recovery following planned treatment cessation. The reasons for the better outcomes in children remain unknown but may be related to increased thymic output and diversity of T cell receptor repertoires. HIV-1 infected children from the PENTA 11 trial tolerated planned treatment interruption without adverse long-term clinical, virological, or immunological consequences, once antiretroviral therapy was re-introduced.
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