Publications by authors named "Katrine Cramer"
Effects of cognitive training under hypoxia on cognitive proficiency and neuroplasticity in remitted patients with mood disorders and healthy individuals: ALTIBRAIN study protocol for a randomized controlled trial.
Trials
October 2024
Article Synopsis
- Cognitive impairment is common in neuropsychiatric disorders, and current treatments lack lasting efficacy; this study aims to explore how altitude-like hypoxia combined with cognitive training might enhance cognition and promote neuroplasticity.
- The research involves two sub-studies: one with 120 healthy participants undergoing different combinations of hypoxia and cognitive training, and another with 60 patients recovering from major depressive disorders comparing hypoxia training to standard treatment.
- Assessments will evaluate cognitive, psychosocial, and quality of life metrics before, immediately after, and one month after treatment, with advanced imaging techniques to assess brain function and synaptic changes, intending to identify measurable cognitive improvements.
Background: Persistent cognitive impairment is frequent across bipolar disorder (BD) and major depressive disorder (MDD), highlighting an urgent need for pro-cognitive treatments.
Aim: This study investigated effects of erythropoietin (EPO) on cognitive impairment and dorsal prefrontal cortex (dPFC) activity in affective disorders.
Methods: In this randomized, double-blinded, placebo-controlled trial, cognitively impaired patients with remitted BD or MDD received 1 weekly recombinant human EPO (40,000 IU/mL) or saline infusion for a 12-week period.
Electroconvulsive therapy (ECT) is one of the most effective and rapid-acting treatment for severe depression but is associated with cognitive side-effects. Identification of add-on treatments that counteract these side-effects would be very helpful. This randomized, double-blinded, placebo-controlled, parallel-group study investigated the effects of four add-on erythropoietin (EPO; 40,000 IU/ml) or saline (placebo) infusions over 2.
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