Prophylactic bilateral Salpingo-oophorectomy and eventual development of endometrial cancer: Two individual case reports.

Prophylactic bilateral salpingo-oophorectomy (PBSO) is regularly performed when patients have a high risk of developing ovarian cancer (i.e. a personal or family history).

Metastatic brain disease in early stage ovarian cancer: A case report.

Ovarian cancer rarely metastasizes to the brain. If it does, it is more likely to occur with advanced stage carcinomas, more than one year after diagnosis, and rarely presents as a single lesion. Early detection, treatment, and close follow-up is essential to optimize prognosis and prevent long-term disability.

STAT1-associated intratumoural T1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancer.

High-grade serous ovarian carcinoma (HGSC) accounts for 70% of all epithelial ovarian cancers but clinical management is challenged by a lack of accurate prognostic and predictive biomarkers of chemotherapy response. This study evaluated the role of Signal Transducer and Activator of Transcription 1 (STAT1) as an independent prognostic and predictive biomarker and its correlation with intratumoural CD8 T cells in a second independent biomarker validation study. Tumour STAT1 expression and intratumoural CD8 T cell infiltration were assessed by immunohistochemistry as a multicentre validation study conducted on 734 chemotherapy-naïve HGSCs.

Current state of biomarkers in ovarian cancer prognosis.

High-grade serous ovarian cancer remains one of the most lethal malignancies in women. Despite recent advances in surgical and pharmaceutical therapies, survival rates remain poor. A major impediment in management of this disease, that continues to contribute to poor overall survival rates, is resistance to standard carboplatin-paclitaxel combination chemotherapies.