An evaluation of the ocular drying effects of 2 systemic antihistamines: loratadine and cetirizine hydrochloride.

Background: Systemic antihistamines, such as loratadine and cetrizine hydrochloride, have proven efficacious in the control of many allergic conditions; however, patients complain about their drying effects.

Objective: To investigate the ocular drying effects of loratadine and cetirizine hydrochloride in individuals with normal ocular health exposed to a controlled adverse environment (CAE).

Methods: Eighteen individuals completed a randomized, double-masked study.

Evaluation of the comfort of Alphagan P compared with Alphagan in irritated eyes.

The tolerability of brimonidine tartrate 0.15%--referred to as bromonidine-Purite 0.15% in this study--was compared with brimonidine tartrate 0.