In vivo cardiac role of migfilin during experimental pressure overload.

Aims: Increased myocardial wall strain triggers the cardiac hypertrophic response by increasing cardiomyocyte size, reprogramming gene expression, and enhancing contractile protein synthesis. The LIM protein, migfilin, is a cytoskeleton-associated protein that was found to translocate in vitro into the nucleus in a Ca(2+)-dependent manner, where it co-activates the pivotal cardiac transcription factor Csx/Nkx2.5.

Association of copeptin with myocardial infarct size and myocardial function after ST segment elevation myocardial infarction.

Objective: To investigate the relationship between circulating plasma copeptin values and infarct size as well as myocardial function at baseline and 4 months after mechanical reperfusion for ST segment elevation myocardial infarction (STEMI).

Design: Prospective observational cohort study.

Setting: University Hospital of Innsbruck.