Publications by authors named "Katrin Sasse"
Purpose: The self-shielding radiosurgery system ZAP-X consists of a 3 MV linear accelerator and eight round collimators. For this system, it is a common practice to perform the reference dosimetry using the largest 25 mm diameter collimator at a source-to-axis distance (SAD) of 45 cm with the PTW Semiflex3D chamber placed at a measurement depth of 7 mm in water. Existing dosimetry protocols do not provide correction for these measurement conditions.
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- The ZAP-X system is an innovative radiosurgical option using a 3 MV linear accelerator and varying collimator cone sizes aimed at early-stage treatments, which minimizes harm to healthy tissue.
- A new 3 mm collimator cone has been developed for the ZAP-X, and the study aimed to assess the effectiveness of a commercial diode detector, the microSilicon, for measuring dosimetric properties and understanding the small field effects.
- Results indicate that the microSilicon detector accurately characterizes the 3 mm beam's dosimetric properties, with high correlation between measurements from the detector and films, confirming its suitability for small field conditions in radiosurgery.
Background: Kynurenine, a metabolite of the L-tryptophan pathway, plays a pivotal role in neuro-inflammation, cancer immunology, and cardiovascular inflammation, and has been shown to predict cardiovascular events.
Objectives: It was our objective to increase the body of data regarding the value of kynurenine as a biomarker in chronic heart failure (CHF).
Methods: We investigated the predictive value of plasma kynurenine in a CHF cohort (CHF, n = 114); in a second cohort of defibrillator carriers with CHF (AICD, n = 156), we determined clinical and biochemical determinants of the marker which was measured by enzyme immunoassay.