Publications by authors named "Katrin Grothaus"
Article Synopsis
- Gene duplication through retrotransposition involves creating a cDNA from mRNA and integrating it back into the genome, influencing evolution.
- A study analyzing monocyte DNA found that while most human CpG islands (CGIs) are unmethylated, 68% of those linked to retrocopies are methylated.
- The research suggests that the methylation state of retrocopies is affected by their surrounding genomic environment, with some displaying maternal methylation imprints, highlighting the role of methylation dynamics in evolutionary processes.
The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5 mC) into 5-hydroxymethylcytosine (5 hmC) and has been shown to be involved in active and passive DNA demethylation. Here, we demonstrate that altering TET dioxygenase levels within physiological range can affect DNA methylation dynamics of HEK293 cells. Overexpression of TET1 increased global 5 hmC levels and was accompanied by mild DNA demethylation of promoters, gene bodies and CpG islands.
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